benzyl N-[(10S,12S,16S)-12-amino-20-methyl-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.0^2,7.0^10,14]hexacosa-1⁽²⁶⁾,2,4,6,22,24-hexaen-16-yl]carbamate hydrochloride

Base Information

• Chemical Name: benzyl N-[(10S,12S,16S)-12-amino-20-methyl-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.0^2,7.0^10,14]hexacosa-1⁽²⁶⁾,2,4,6,22,24-hexaen-16-yl]carbamate hydrochloride
• CAS No.: 1460301-53-4
• Molecular Formula: C₃₂H₃₆N₄O₅*ClH
• Molecular Weight: 593.123

Synonyms:benzyl N-[(10S,12S,16S)-12-amino-20-methyl-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.0^2,7.0^10,14]hexacosa-1⁽²⁶⁾,2,4,6,22,24-hexaen-16-yl]carbamate hydrochloride

Chemical Property of benzyl N-[(10S,12S,16S)-12-amino-20-methyl-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.0^2,7.0^10,14]hexacosa-1⁽²⁶⁾,2,4,6,22,24-hexaen-16-yl]carbamate hydrochloride

Chemical Property:

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Technology Process of benzyl N-[(10S,12S,16S)-12-amino-20-methyl-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.0^2,7.0^10,14]hexacosa-1⁽²⁶⁾,2,4,6,22,24-hexaen-16-yl]carbamate hydrochloride

There total 12 articles about benzyl N-[(10S,12S,16S)-12-amino-20-methyl-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.0^2,7.0^10,14]hexacosa-1⁽²⁶⁾,2,4,6,22,24-hexaen-16-yl]carbamate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl N-[(10S,12S,16S)-12-[(tert-butoxycarbonyl)amino]-20-methyl-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.02'7.01014]hexacosa-1(26),2,4,6,22,24-hexaen-16-yl]carbamate → benzyl N-[(10S,12S,16S)-12-amino-20-methyl-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.02,7.010,14]hexacosa-1(26),2,4,6,22,24-hexaen-16-yl]carbamate hydrochloride (1460301-53-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

Reference yield: 100.0%

benzyl N-[(10S,12S,16S)-12-[(tert-butoxycarbonyl)amino]-20-methyl-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.02,7.010,14]hexacosa-1(26),2,4,6,22,24-hexaen-16-yl]carbamate → benzyl N-[(10S,12S,16S)-12-amino-20-methyl-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.02,7.010,14]hexacosa-1(26),2,4,6,22,24-hexaen-16-yl]carbamate hydrochloride (1460301-53-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

Reference yield:

C27H32N2O7 (1460306-74-4) → benzyl N-[(10S,12S,16S)-12-amino-20-methyl-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.02,7.010,14]hexacosa-1(26),2,4,6,22,24-hexaen-16-yl]carbamate hydrochloride (1460301-53-4)

Guidance literature:

Multi-step reaction with 4 steps

1: HATU; 1-hydroxy-7-aza-benzotriazole / N,N-dimethyl-formamide / 15 h / 0 - 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid / dichloromethane; ethyl acetate / 1 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane; ethyl acetate / 2 h

4: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1-hydroxy-7-aza-benzotriazole; 1,3-dimethylbarbituric acid; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

2′-hydroxy[1,1-biphenyl]-3-carboxylic acid

C₂₈H₃₄N₂O₇

C₂₇H₃₂N₂O₇

(S)-allyl 2-(benzyloxycarbonylamino)-5-(methylamino)pentanoate hydrochloride

Downstream raw materials:

N-[(10S,12S,16S)-20-methyl-15,21-dioxo-16-[(2-phenylacetyl)amino]-8-oxa-14,20-diazatetracyclo[20.3.1.0²'⁷.0¹⁰'¹⁴]hexacosa-1⁽²⁶⁾,2,4,6,22,24-hexaen-12-yl]-2-(2-naphthyl)acetamide

N-[(10S,12S,16S)-20-methyl-12-{[2-(2-naphthyl)acetyl]amino}-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.0²'⁷.0¹⁰¹⁴]exacosa-1⁽²⁶⁾,2,4,6,22,24-hexaen-16-yl]benzamide

benzyl (9S,14S)-9,15-dimethyl-11,16-dioxo-7-oxa-10,15-diazatricyclo[15.3.1.1²'⁶]docosa-1⁽²¹⁾,2⁽²²⁾,3,5,17,19-hexaene-14-carboxylate

benzyl N-[(10S,12S,16S)-20-methyl-12-{[2-(2-naphthyl)acetyl]amino}-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.0²'⁷.0¹⁰¹⁴]hexacosa-1⁽²⁶⁾,2,4,6,22,24-hexaen-16-yl]carbamate

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