methyl 6-(4-(4-cyanotetrahydro-2H-pyran-4-yl)-2,6-difluorophenyl)-5-fluoropicolinate

Base Information

Chemical Name:methyl 6-(4-(4-cyanotetrahydro-2H-pyran-4-yl)-2,6-difluorophenyl)-5-fluoropicolinate
CAS No.:1395283-14-3
Molecular Formula:C₁₉H₁₅F₃N₂O₃
Molecular Weight:376.335
Hs Code.:

Synonyms:methyl 6-(4-(4-cyanotetrahydro-2H-pyran-4-yl)-2,6-difluorophenyl)-5-fluoropicolinate

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Chemical Property of methyl 6-(4-(4-cyanotetrahydro-2H-pyran-4-yl)-2,6-difluorophenyl)-5-fluoropicolinate

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Technology Process of methyl 6-(4-(4-cyanotetrahydro-2H-pyran-4-yl)-2,6-difluorophenyl)-5-fluoropicolinate

There total 4 articles about methyl 6-(4-(4-cyanotetrahydro-2H-pyran-4-yl)-2,6-difluorophenyl)-5-fluoropicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 5414-19-7
1,1'-oxybis(2-bromo-ethane)

: 1395283-05-2
methyl 6-(4-(cyanomethyl)-2,6-difluorophenyl)-5-fluoropicolinate

: 1395283-14-3
methyl 6-(4-(4-cyanotetrahydro-2H-pyran-4-yl)-2,6-difluorophenyl)-5-fluoropicolinate

Guidance literature:: methyl 6-(4-(cyanomethyl)-2,6-difluorophenyl)-5-fluoropicolinate; With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 0.25h;

1,1'-oxybis(2-bromo-ethane); In dimethyl sulfoxide; at 20 ℃; for 0.5h;

Reference yield:

: 1395280-83-7
methyl 6-(2,6-difluoro-4-formylphenyl)-5-fluoropicolinate

: 1395283-14-3
methyl 6-(4-(4-cyanotetrahydro-2H-pyran-4-yl)-2,6-difluorophenyl)-5-fluoropicolinate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium borohydrid / water; tetrahydrofuran

2: triphenylphosphine; bromine / 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

3: sodium cyanide / water; quinoclamine

4: sodium hydride / dimethyl sulfoxide

With sodium cyanide; sodium hydride; sodium borohydrid; bromine; triphenylphosphine; In tetrahydrofuran; quinoclamine; water; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; dimethyl sulfoxide;

Reference yield:

: 1395280-89-3
methyl 6-(2,6-difluoro-4-(hydroxymethyl)phenyl)-5-fluoropicolinate

: 1395283-14-3
methyl 6-(4-(4-cyanotetrahydro-2H-pyran-4-yl)-2,6-difluorophenyl)-5-fluoropicolinate

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; bromine / 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

2: sodium cyanide / water; quinoclamine

3: sodium hydride / dimethyl sulfoxide

With sodium cyanide; sodium hydride; bromine; triphenylphosphine; In quinoclamine; water; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; dimethyl sulfoxide;