(S)-1-{(S)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-[(S)-2-((2R,3R)-3-methoxy-2-methylhept-6-enoylamino)-3-methylbutyrylamino]propionyl}hexahydropyridazine-3-carboxylic acid 3-vinylbenzyl ester

Base Information

Chemical Name:(S)-1-{(S)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-[(S)-2-((2R,3R)-3-methoxy-2-methylhept-6-enoylamino)-3-methylbutyrylamino]propionyl}hexahydropyridazine-3-carboxylic acid 3-vinylbenzyl ester
CAS No.:1381812-25-4
Molecular Formula:C₄₃H₆₄N₄O₇Si
Molecular Weight:777.089
Hs Code.:

(S)-1-{(S)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-[(S)-2-((2R,3R)-3-methoxy-2-methylhept-6-enoylamino)-3-methylbutyrylamino]propionyl}hexahydropyridazine-3-carboxylic acid 3-vinylbenzyl ester

Synonyms:(S)-1-{(S)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-[(S)-2-((2R,3R)-3-methoxy-2-methylhept-6-enoylamino)-3-methylbutyrylamino]propionyl}hexahydropyridazine-3-carboxylic acid 3-vinylbenzyl ester

Suppliers and Price of (S)-1-{(S)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-[(S)-2-((2R,3R)-3-methoxy-2-methylhept-6-enoylamino)-3-methylbutyrylamino]propionyl}hexahydropyridazine-3-carboxylic acid 3-vinylbenzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-1-{(S)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-[(S)-2-((2R,3R)-3-methoxy-2-methylhept-6-enoylamino)-3-methylbutyrylamino]propionyl}hexahydropyridazine-3-carboxylic acid 3-vinylbenzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-1-{(S)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-[(S)-2-((2R,3R)-3-methoxy-2-methylhept-6-enoylamino)-3-methylbutyrylamino]propionyl}hexahydropyridazine-3-carboxylic acid 3-vinylbenzyl ester

There total 10 articles about (S)-1-{(S)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-[(S)-2-((2R,3R)-3-methoxy-2-methylhept-6-enoylamino)-3-methylbutyrylamino]propionyl}hexahydropyridazine-3-carboxylic acid 3-vinylbenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1381812-18-5
(2R,3R)-3-methoxy-2-methyl-hept-6-enoic acid

: 1381812-31-2
(S)-1-{(S)-2-((S)-2-amino-3-methylbutyrylamino)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]propionyl}hexahydropyridazine-3-carboxylic acid 3-vinylbenzyl ester

: 1381812-25-4
(S)-1-{(S)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-[(S)-2-((2R,3R)-3-methoxy-2-methylhept-6-enoylamino)-3-methylbutyrylamino]propionyl}hexahydropyridazine-3-carboxylic acid 3-vinylbenzyl ester

Guidance literature:: (2R,3R)-3-methoxy-2-methyl-hept-6-enoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h; Inert atmosphere;

(S)-1-{(S)-2-((S)-2-amino-3-methylbutyrylamino)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]propionyl}hexahydropyridazine-3-carboxylic acid 3-vinylbenzyl ester; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 45804-94-2
3-Ethenylbenzyl alcohol

: 1381812-25-4
(S)-1-{(S)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-[(S)-2-((2R,3R)-3-methoxy-2-methylhept-6-enoylamino)-3-methylbutyrylamino]propionyl}hexahydropyridazine-3-carboxylic acid 3-vinylbenzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 6 h / 20 - 40 °C / Inert atmosphere

2.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1.5 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

3.2: 16 h / 0 - 20 °C / Inert atmosphere

With trimethylsilyl trifluoromethanesulfonate; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1381811-94-4
(S)-1-{(S)-2-((S)-2-tert-butoxycarbonylamino-3-methylbutyrylamino)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]propionyl}hexahydropyridazine-3-carboxylic acid 3-vinylbenzyl ester

: 1381812-25-4
(S)-1-{(S)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-[(S)-2-((2R,3R)-3-methoxy-2-methylhept-6-enoylamino)-3-methylbutyrylamino]propionyl}hexahydropyridazine-3-carboxylic acid 3-vinylbenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1.5 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

2.2: 16 h / 0 - 20 °C / Inert atmosphere

With trimethylsilyl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide;