N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinazolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Base Information

Chemical Name:N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinazolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
CAS No.:849217-67-0
Molecular Formula:C₃₃H₃₃F₂N₅O₆
Molecular Weight:633.652
Hs Code.:

Synonyms:N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinazolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

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Chemical Property of N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinazolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

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Technology Process of N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinazolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

There total 12 articles about N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinazolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 4441-30-9
3-morpholin-4-ylpropan-1-ol

: 849217-66-9
cyclopropane-1,1-dicarboxylic acid [3-fluoro-4-(7-hydroxy-6-methoxy-quinazolin-4-yloxy)-phenyl]-amide-(4-fluoro-phenyl)-amide

: 849217-67-0
N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinazolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 849217-58-9
N'-(3-fluoro-4-hydroxyphenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

: 849217-67-0
N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinazolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / ISOPROPYLAMIDE / 16 h / 50 °C

2: hydrogen; acetic acid / palladium 10% on activated carbon / methanol; dichloromethane / 4 h / 2068.65 Torr

3: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 16 h / 20 °C

With di-isopropyl azodicarboxylate; hydrogen; potassium carbonate; acetic acid; triphenylphosphine; palladium 10% on activated carbon; In methanol; dichloromethane; ISOPROPYLAMIDE;

Reference yield:

: 168268-00-6
4-(benzyloxy)-3-fluoroaniline

: 849217-67-0
N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinazolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

2: cyclohexa-1,4-diene / palladium 10% on activated carbon / ethanol / 2 h / Heating / reflux

3: potassium carbonate / ISOPROPYLAMIDE / 16 h / 50 °C

4: hydrogen; acetic acid / palladium 10% on activated carbon / methanol; dichloromethane / 4 h / 2068.65 Torr

5: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 16 h / 20 °C

With cyclohexa-1,4-diene; di-isopropyl azodicarboxylate; hydrogen; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; ISOPROPYLAMIDE;