cyclopropane-1,1-dicarboxylic acid [3-fluoro-4-(7-hydroxy-6-methoxy-quinazolin-4-yloxy)-phenyl]-amide-(4-fluoro-phenyl)-amide

Base Information

Chemical Name:cyclopropane-1,1-dicarboxylic acid [3-fluoro-4-(7-hydroxy-6-methoxy-quinazolin-4-yloxy)-phenyl]-amide-(4-fluoro-phenyl)-amide
CAS No.:849217-66-9
Molecular Formula:C₂₆H₂₀F₂N₄O₅
Molecular Weight:506.465
Hs Code.:

Synonyms:cyclopropane-1,1-dicarboxylic acid [3-fluoro-4-(7-hydroxy-6-methoxy-quinazolin-4-yloxy)-phenyl]-amide-(4-fluoro-phenyl)-amide

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Chemical Property of cyclopropane-1,1-dicarboxylic acid [3-fluoro-4-(7-hydroxy-6-methoxy-quinazolin-4-yloxy)-phenyl]-amide-(4-fluoro-phenyl)-amide

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Technology Process of cyclopropane-1,1-dicarboxylic acid [3-fluoro-4-(7-hydroxy-6-methoxy-quinazolin-4-yloxy)-phenyl]-amide-(4-fluoro-phenyl)-amide

There total 12 articles about cyclopropane-1,1-dicarboxylic acid [3-fluoro-4-(7-hydroxy-6-methoxy-quinazolin-4-yloxy)-phenyl]-amide-(4-fluoro-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 849217-65-8
cyclopropane-1,1-dicarboxylic acid [4-(7-benzyloxy-6-methoxy-quinazolin-4-yloxy)-3-fluoro-phenyl]-amide-(4-fluoro-phenyl)-amide

: 849217-66-9
cyclopropane-1,1-dicarboxylic acid [3-fluoro-4-(7-hydroxy-6-methoxy-quinazolin-4-yloxy)-phenyl]-amide-(4-fluoro-phenyl)-amide

Guidance literature:: With hydrogen; acetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; for 4h; under 2068.65 Torr;

Reference yield:

: 168268-00-6
4-(benzyloxy)-3-fluoroaniline

: 849217-66-9
cyclopropane-1,1-dicarboxylic acid [3-fluoro-4-(7-hydroxy-6-methoxy-quinazolin-4-yloxy)-phenyl]-amide-(4-fluoro-phenyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

2: cyclohexa-1,4-diene / palladium 10% on activated carbon / ethanol / 2 h / Heating / reflux

3: potassium carbonate / ISOPROPYLAMIDE / 16 h / 50 °C

4: hydrogen; acetic acid / palladium 10% on activated carbon / methanol; dichloromethane / 4 h / 2068.65 Torr

With cyclohexa-1,4-diene; hydrogen; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; ISOPROPYLAMIDE;

Reference yield:

: 76243-24-8
1-(benzyloxy)-2-fluoro-4-nitrobenzene

: 849217-66-9
cyclopropane-1,1-dicarboxylic acid [3-fluoro-4-(7-hydroxy-6-methoxy-quinazolin-4-yloxy)-phenyl]-amide-(4-fluoro-phenyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium formate; iron / water; toluene / Heating / reflux

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

3: cyclohexa-1,4-diene / palladium 10% on activated carbon / ethanol / 2 h / Heating / reflux

4: potassium carbonate / ISOPROPYLAMIDE / 16 h / 50 °C

5: hydrogen; acetic acid / palladium 10% on activated carbon / methanol; dichloromethane / 4 h / 2068.65 Torr

With cyclohexa-1,4-diene; hydrogen; ammonium formate; iron; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; ISOPROPYLAMIDE; water; toluene;