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5-3-(Dimethylamino)propyl-10,11-dihydro-5H-dibenz[b, f]-azepine monohydrochloride

Base Information Edit
  • Chemical Name:5-3-(Dimethylamino)propyl-10,11-dihydro-5H-dibenz[b, f]-azepine monohydrochloride
  • CAS No.:113-52-0
  • Molecular Formula:C19H25ClN2
  • Molecular Weight:316.874
  • Hs Code.:2933995800
  • Mol file:113-52-0.mol
5-3-(Dimethylamino)propyl-10,11-dihydro-5H-dibenz[b, f]-azepine monohydrochloride

Synonyms:5-3-(Dimethylamino)propyl-10,11-dihydro-5H-dibenz[ b, f]-azepine monohydrochloride

Suppliers and Price of 5-3-(Dimethylamino)propyl-10,11-dihydro-5H-dibenz[b, f]-azepine monohydrochloride
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • Imipramine Hydrochloride
  • 1g
  • $ 45.00
  • TRC
  • Imipramine Hydrochloride
  • 50g
  • $ 400.00
  • TCI Chemical
  • Imipramine Hydrochloride >98.0%(HPLC)
  • 5g
  • $ 122.00
  • TCI Chemical
  • Imipramine Hydrochloride >98.0%(HPLC)
  • 1g
  • $ 42.00
  • TCI Chemical
  • Imipramine Hydrochloride >98.0%(HPLC)
  • 25g
  • $ 502.00
  • Sigma-Aldrich
  • Imipramine hydrochloride ≥99% (TLC)
  • 100g
  • $ 408.00
  • Sigma-Aldrich
  • Imipramine hydrochloride BioXtra, ≥99% (TLC)
  • 5g
  • $ 86.70
  • Sigma-Aldrich
  • Imipramine hydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
  • 1 mL
  • $ 20.90
  • Sigma-Aldrich
  • Imipramine hydrochloride solution 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material
  • 902-1ml
  • $ 20.30
  • Sigma-Aldrich
  • Imipramine hydrochloride European Pharmacopoeia (EP) Reference Standard
  • $ 190.00
Total 101 raw suppliers
Chemical Property of 5-3-(Dimethylamino)propyl-10,11-dihydro-5H-dibenz[b, f]-azepine monohydrochloride Edit
Chemical Property:
  • Appearance/Colour:UN 1230 3/PG 2 
  • Vapor Pressure:6.6E-06mmHg at 25°C 
  • Melting Point:168-170 °C 
  • Boiling Point:403.1 °C at 760 mmHg 
  • Flash Point:179.7 °C 
  • PSA:6.48000 
  • Density:1.041g/cm3 
  • LogP:4.74200 
  • Storage Temp.:2-8°C 
  • Solubility.:H2O: 50 mg/mL 
  • Water Solubility.:Soluble in water 
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:3
  • Rotatable Bond Count:4
  • Exact Mass:316.1706265
  • Heavy Atom Count:22
  • Complexity:291
Purity/Quality:

99% *data from raw suppliers

Imipramine Hydrochloride *data from reagent suppliers

Safty Information:
  • Pictogram(s): HarmfulXn 
  • Hazard Codes:Xn,T,F 
  • Statements: 23/25-36/38-36/37/38-22-39/23/24/25-23/24/25-11 
  • Safety Statements: 7-16-24-33-45-36-26-36/37 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Canonical SMILES:[H+].CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31.[Cl-]
  • Uses Tricyclic antidepressant; inhibits the serotonin and norepinephrine transporters. Has little effect on the dopamine transporter Antidepressant;5-HT transport inhibitor Imipramine hydrochloride is used as a serotonin uptake inhibitor. It mainly used in the treatment of major depression and enuresis (inability to control urination). It has also been evaluated for use in panic disorder.
  • Therapeutic Function Antidepressant
  • Clinical Use The demethylated metabolite is less anticholinergic, lesssedative, and more stimulatory and is a SNERI.Consequently, a patient treated with imipramine has twocompounds that contribute to activity. Overall, the effect isnonselective 5-HT versus NE reuptake.
  • Drug interactions Potentially hazardous interactions with other drugs Alcohol: increased sedative effect. Analgesics: increased risk of CNS toxicity with tramadol; possibly increased risk of side effects with nefopam; possibly increased sedative effects with opioids. Anti-arrhythmics: increased risk of ventricular arrhythmias with amiodarone - avoid; increased risk of ventricular arrhythmias with disopyramide, flecainide or propafenone; avoid with dronedarone. Antibacterials: increased risk of ventricular arrhythmias with delamanid, moxifloxacin and possibly telithromycin - avoid with delamanid and moxifloxacin. Anticoagulants: may alter anticoagulant effect of coumarins. Antidepressants: enhanced CNS excitation and hypertension with MAOIs and moclobemide - avoid; concentration possibly increased with SSRIs; risk of ventricular arrhythmias with citalopram and escitalopram - avoid; possible increased risk of convulsions with vortioxetine. Antiepileptics: convulsive threshold lowered; concentration reduced by carbamazepine, phenobarbital and possibly fosphenytoin, phenytoin and primidone. Antimalarials: avoid with artemether/lumefantrine and piperaquine with artenimol. Antipsychotics: increased risk of ventricular arrhythmias especially with droperidol, fluphenazine, haloperidol, pimozide, sulpiride and zuclopenthixol - avoid; increased antimuscarinic effects with clozapine and phenothiazines; concentration increased by antipsychotics. Antivirals: increased risk of ventricular arrhythmias with saquinavir - avoid; concentration possibly increased with ritonavir. Atomoxetine: increased risk of ventricular arrhythmias and possibly convulsions. Beta-blockers: increased risk of ventricular arrhythmias with sotalol; concentration increased by labetalol and propranolol. Clonidine: tricyclics antagonise hypotensive effect; increased risk of hypertension on clonidine withdrawal. Dapoxetine: possibly increased risk of serotonergic effects - avoid. Dopaminergics: avoid use with entacapone; CNS toxicity reported with selegiline and rasagiline. Pentamidine: increased risk of ventricular arrhythmias. Sympathomimetics: increased risk of hypertension and arrhythmias with adrenaline and noradrenaline; metabolism possibly inhibited by methylphenidate.
Technology Process of 5-3-(Dimethylamino)propyl-10,11-dihydro-5H-dibenz[b, f]-azepine monohydrochloride

There total 1 articles about 5-3-(Dimethylamino)propyl-10,11-dihydro-5H-dibenz[b, f]-azepine monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
In acetone; for 0.5h; Heating / reflux;
In di-isopropyl ether; at 0 - 5 ℃;
Guidance literature:
In water; at 20 - 62 ℃; for 19.95h;
Guidance literature:
With peroxidase from horseradish type VI; dihydrogen peroxide; at 37 ℃; for 1h; pH=7; aq. phosphate buffer; Enzymatic reaction;
DOI:10.1021/tx100221b
Refernces Edit
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