Sodium salicylate

Base Information

• Chemical Name: Sodium salicylate
• CAS No.: 54-21-7
• Molecular Formula: C7H5NaO3
• Molecular Weight: 160.105
• Hs Code.: 2918.21
• Mol file: 54-21-7.mol

Synonyms:Parbocyl-Rev;CLIN;Kerosal;Sodium 2-hydroxybenzoate;Sodium o-hydroxybenzoate;o-Hydroxybenzoic acid, sodium salt;Salsonin (TN);Enterosalil;Diuretin;Entrosalyl;Salicylic acid Na+;Aroall;Sodium salicylic acid;Salsonin;Nadisal;Magsalyl;Salisod;Benzoic acid, 2-hydroxy-, monosodium salt;Salicylic acid, sodium salt;Kerasalicyl;Alysine;Sodium salicylate (NaO3C7H5);Neo-Salicyl;Salicylic acid, monosodium salt;Benzoic acid,2-hydroxy-,compounds,monosodium salt;Sodium salicylate (JP14/USP);Monosodium salicylate;Glutosalyl;o-Hydroxybenzoic sodium salt;Salicylate, sodium;

Chemical Property of Sodium salicylate

Chemical Property:

• Appearance/Colour: white crystals
• Melting Point: 200 °C
• Boiling Point: 336.3 °C at 760 mmHg
• Flash Point: 144.5 °C
• PSA: 60.36000
• Density: 0.32 g/cm3 (20℃)
• LogP: -0.24430
• Storage Temp.: +15C to +30C
• Sensitive.: Light Sensitive
• Solubility.: 1000g/l
• Water Solubility.: 1000 g/L (20 ºC)

Purity/Quality:

99.0-101.0% ^*data from raw suppliers

Sodium Salicylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi, Xn
• Hazard Codes: Xn,Xi
• Statements: 22-41-36/37/38-36
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Description: Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure. Historically, it has been synthesized from methyl salicylate (found in wintergreen plants or the bark of sweet birch tree) by reacting it with an excess of sodium hydroxide and heating it under reflux.
• Uses: In manufacture of aspirin, methyl salicylate, and other salicylates. Coupling agent for azo dyes. Has been used as food preservative. It is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non - steroidal anti - inflammatory drug (NSAID), and induces apoptosis in cancer cells and also necrosis. It is also a potential replacement for aspirin for people sensitive to it. It may also be used as a phosphor for the detection of vacuum ultra violet radiation and electrons.

Technology Process of Sodium salicylate

There total 22 articles about Sodium salicylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

salicylic acid (69-72-7,25496-36-0,8052-31-1) → salicylic acid disodium salt (54-21-7,13639-21-9,79211-80-6)

Guidance literature:

With sodium hydroxide; In methanol; water;

DOI:10.1021/jacs.1c08615

Reference yield: 80.0%

carbon dioxide (124-38-9,18923-20-1) + sodium phenoxide (139-02-6) → sodium salicylate (54-21-7) + sodium 4-hydroxybenzoate (114-63-6)

Guidance literature:

With Triethylene glycol dimethyl ether; at 80 ℃; for 10h; Product distribution; var. polyethers;

DOI:10.1246/bcsj.53.279

Reference yield: 12.0%

sodium 2-methoxybenzoate (17264-78-7) → sodium salicylate (54-21-7)

Guidance literature:

With piperazine; In N,N-dimethyl acetamide; at 150 ℃; for 24h;

DOI:10.1055/s-2000-6244

upstream raw materials:

bis(phenyl) carbonate

sodium ethanolate

ethyl phenyl carbonate

sodium phenoxide

Downstream raw materials:

2-hydroxy-benzoic acid thiophen-2-ylmethyl ester

1-(4-methyl-thiazol-5-yl)-2-salicyloyloxy-ethane

acetylsalicylsalicylic acid

salicylic acid-(β,β'-dichloro-isopropyl ester)

Refernces

• 1、 -. "Synthetic method of methyl salicylate". . . Retrieved 2021/02/10.
• 2、 -. "SAA DERIVATIVE COMPOUND RESTORES ENOS AND INHIBITS OXIDATIVE STRESS-INDUCED DISEASES IN HYPOXIA". Paragraph 00219; 00220. . Retrieved 2015/11/10.