(1E,3R,4R)-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-phenyl-1,6-heptadien-4-amine

Base Information

Chemical Name:(1E,3R,4R)-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-phenyl-1,6-heptadien-4-amine
CAS No.:1297139-08-2
Molecular Formula:C₁₉H₃₁NOSi
Molecular Weight:317.547
Hs Code.:

Synonyms:(1E,3R,4R)-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-phenyl-1,6-heptadien-4-amine

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Chemical Property of (1E,3R,4R)-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-phenyl-1,6-heptadien-4-amine

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Technology Process of (1E,3R,4R)-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-phenyl-1,6-heptadien-4-amine

There total 4 articles about (1E,3R,4R)-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-phenyl-1,6-heptadien-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1297139-05-9
(1E,3R,4R)-4-amino-1-phenyl-1,6-heptadien-3-ol

: 69739-34-0
t-butyldimethylsiyl triflate

: 1297139-08-2
(1E,3R,4R)-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-phenyl-1,6-heptadien-4-amine

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 - 20 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 1297139-00-4
(4S)-3-[(2R,3R,4E)-3-hydroxy-5-phenyl-2-(2-propen-1-yl)-4-pentenoyl]-4-(phenylmethyl)-1,3-oxazolidin-2-one

: 1297139-08-2
(1E,3R,4R)-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-phenyl-1,6-heptadien-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 0 - 20 °C

1.2: pH ~ 2

2.1: triethylamine; diphenylphosphoranyl azide / toluene / 80 °C

3.1: potassium hydroxide; water / ethanol / 80 °C

3.2: pH ~ 8

4.1: 2,6-dimethylpyridine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; lithium hydroxide monohydrate; diphenylphosphoranyl azide; water; dihydrogen peroxide; triethylamine; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;

Reference yield:

: 1297139-01-5
(2R,3R,4E)-3-hydroxy-5-phenyl-2-(2-propen-1-yl)-4-pentenoic acid

: 1297139-08-2
(1E,3R,4R)-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-phenyl-1,6-heptadien-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; diphenylphosphoranyl azide / toluene / 80 °C

2.1: potassium hydroxide; water / ethanol / 80 °C

2.2: pH ~ 8

3.1: 2,6-dimethylpyridine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; diphenylphosphoranyl azide; water; triethylamine; potassium hydroxide; In ethanol; dichloromethane; toluene;