1-[(1R,2R,3E)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-4-phenyl-1-(2-propen-1-yl)-3-buten-1-yl]-4-[(4-nitrophenyl)sulfonyl]-2-piperazinone

Base Information

Chemical Name:1-[(1R,2R,3E)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-4-phenyl-1-(2-propen-1-yl)-3-buten-1-yl]-4-[(4-nitrophenyl)sulfonyl]-2-piperazinone
CAS No.:1297139-10-6
Molecular Formula:C₂₉H₃₉N₃O₆SSi
Molecular Weight:585.797
Hs Code.:

Synonyms:1-[(1R,2R,3E)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-4-phenyl-1-(2-propen-1-yl)-3-buten-1-yl]-4-[(4-nitrophenyl)sulfonyl]-2-piperazinone

Suppliers and Price of 1-[(1R,2R,3E)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-4-phenyl-1-(2-propen-1-yl)-3-buten-1-yl]-4-[(4-nitrophenyl)sulfonyl]-2-piperazinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-[(1R,2R,3E)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-4-phenyl-1-(2-propen-1-yl)-3-buten-1-yl]-4-[(4-nitrophenyl)sulfonyl]-2-piperazinone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[(1R,2R,3E)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-4-phenyl-1-(2-propen-1-yl)-3-buten-1-yl]-4-[(4-nitrophenyl)sulfonyl]-2-piperazinone

There total 8 articles about 1-[(1R,2R,3E)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-4-phenyl-1-(2-propen-1-yl)-3-buten-1-yl]-4-[(4-nitrophenyl)sulfonyl]-2-piperazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1297139-09-3
N₁-[(1R,2R,3E)-2-{[(1,1-dimethylethyl)(dimethyl)silyl] oxy}-4-phenyl-1-(2-propen-1-yl)-3-buten-1-yl]-N₂-[(4-nitrophenyl)sulfonyl]glycinamide

: 106-93-4
ethylene dibromide

: 1297139-10-6
1-[(1R,2R,3E)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-4-phenyl-1-(2-propen-1-yl)-3-buten-1-yl]-4-[(4-nitrophenyl)sulfonyl]-2-piperazinone

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃;

Reference yield:

: 1297139-00-4
(4S)-3-[(2R,3R,4E)-3-hydroxy-5-phenyl-2-(2-propen-1-yl)-4-pentenoyl]-4-(phenylmethyl)-1,3-oxazolidin-2-one

: 1297139-10-6
1-[(1R,2R,3E)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-4-phenyl-1-(2-propen-1-yl)-3-buten-1-yl]-4-[(4-nitrophenyl)sulfonyl]-2-piperazinone

Guidance literature:: Multi-step reaction with 6 steps

1.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 0 - 20 °C

1.2: pH ~ 2

2.1: triethylamine; diphenylphosphoranyl azide / toluene / 80 °C

3.1: potassium hydroxide; water / ethanol / 80 °C

3.2: pH ~ 8

4.1: 2,6-dimethylpyridine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 60 °C

With 2,6-dimethylpyridine; lithium hydroxide monohydrate; diphenylphosphoranyl azide; water; dihydrogen peroxide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1297139-01-5
(2R,3R,4E)-3-hydroxy-5-phenyl-2-(2-propen-1-yl)-4-pentenoic acid

: 1297139-10-6
1-[(1R,2R,3E)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-4-phenyl-1-(2-propen-1-yl)-3-buten-1-yl]-4-[(4-nitrophenyl)sulfonyl]-2-piperazinone

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; diphenylphosphoranyl azide / toluene / 80 °C

2.1: potassium hydroxide; water / ethanol / 80 °C

2.2: pH ~ 8

3.1: 2,6-dimethylpyridine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 60 °C

With 2,6-dimethylpyridine; diphenylphosphoranyl azide; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;