(1R,2S,3S,4R)-2-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-((1S,2S)-1-hydroxy-3-((4-methoxybenzyl)oxy)-2-methylpropyl)-4-methyl-3-((triisopropylsilyl)oxy)cyclopentan-1-ol

Base Information

Chemical Name:(1R,2S,3S,4R)-2-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-((1S,2S)-1-hydroxy-3-((4-methoxybenzyl)oxy)-2-methylpropyl)-4-methyl-3-((triisopropylsilyl)oxy)cyclopentan-1-ol
CAS No.:1591271-13-4
Molecular Formula:C₃₅H₆₆O₆Si₂
Molecular Weight:639.076
Hs Code.:

(1R,2S,3S,4R)-2-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-((1S,2S)-1-hydroxy-3-((4-methoxybenzyl)oxy)-2-methylpropyl)-4-methyl-3-((triisopropylsilyl)oxy)cyclopentan-1-ol

Synonyms:(1R,2S,3S,4R)-2-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-((1S,2S)-1-hydroxy-3-((4-methoxybenzyl)oxy)-2-methylpropyl)-4-methyl-3-((triisopropylsilyl)oxy)cyclopentan-1-ol

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Chemical Property of (1R,2S,3S,4R)-2-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-((1S,2S)-1-hydroxy-3-((4-methoxybenzyl)oxy)-2-methylpropyl)-4-methyl-3-((triisopropylsilyl)oxy)cyclopentan-1-ol

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Technology Process of (1R,2S,3S,4R)-2-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-((1S,2S)-1-hydroxy-3-((4-methoxybenzyl)oxy)-2-methylpropyl)-4-methyl-3-((triisopropylsilyl)oxy)cyclopentan-1-ol

There total 16 articles about (1R,2S,3S,4R)-2-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-((1S,2S)-1-hydroxy-3-((4-methoxybenzyl)oxy)-2-methylpropyl)-4-methyl-3-((triisopropylsilyl)oxy)cyclopentan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: (S)-1-((1R,2S,3S,4R)-2-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-hydroxy-4-methyl-3-((triisopropylsilyl)oxy)cyclopentyl)-3-((4-methoxybenzyl)oxy)-2-methylpropan-1-one

: 1591271-13-4
(1R,2S,3S,4R)-2-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-((1S,2S)-1-hydroxy-3-((4-methoxybenzyl)oxy)-2-methylpropyl)-4-methyl-3-((triisopropylsilyl)oxy)cyclopentan-1-ol

: 1591271-14-5
(1R,2S,3S,4R)-2-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-((1R,2S)-1-hydroxy-3-((4-methoxybenzyl)oxy)-2-methylpropyl)-4-methyl-3-((triisopropylsilyl)oxy)cyclopentan-1-ol

Guidance literature:: With sodium tetrahydroborate; In ethanol; dichloromethane; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1002/ejoc.201301616

Reference yield:

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 1591271-13-4
(1R,2S,3S,4R)-2-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-((1S,2S)-1-hydroxy-3-((4-methoxybenzyl)oxy)-2-methylpropyl)-4-methyl-3-((triisopropylsilyl)oxy)cyclopentan-1-ol

: 1591271-14-5
(1R,2S,3S,4R)-2-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-((1R,2S)-1-hydroxy-3-((4-methoxybenzyl)oxy)-2-methylpropyl)-4-methyl-3-((triisopropylsilyl)oxy)cyclopentan-1-ol

Guidance literature:: Multi-step reaction with 8 steps

1.1: 2,6-dimethylpyridine / dichloromethane / 14 h / 0 °C / Inert atmosphere

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 1 h / Inert atmosphere; Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 °C / Inert atmosphere

4.1: 1H-imidazole / Inert atmosphere

4.2: Inert atmosphere

5.1: copper(l) iodide / diethyl ether / 1 h / -78 - 0 °C / Inert atmosphere

5.2: 1 h / -78 °C / Inert atmosphere

6.1: tert.-butyl lithium / pentane; diethyl ether / 0.58 h / -78 - 20 °C / Inert atmosphere

6.2: 5 h / -78 °C / Inert atmosphere

7.1: pyridine; ozone; Sudan III / methanol; dichloromethane / -78 °C / Inert atmosphere

7.2: 12 h / 20 °C / Inert atmosphere

8.1: sodium tetrahydroborate / dichloromethane; ethanol / 24 h / 20 °C / Inert atmosphere

With pyridine; 1H-imidazole; 2,6-dimethylpyridine; sodium tetrahydroborate; copper(l) iodide; lithium aluminium tetrahydride; tert.-butyl lithium; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; Sudan III; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; pentane;
DOI:10.1002/ejoc.201301616

Reference yield:

: 1591271-00-9
(3aR,4S,6aR)-4-((triisopropylsilyl)oxy)-3,3a,4,6a-tetrahydro-2H-cyclopenta[b]furan-2-one

: 1591271-13-4
(1R,2S,3S,4R)-2-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-((1S,2S)-1-hydroxy-3-((4-methoxybenzyl)oxy)-2-methylpropyl)-4-methyl-3-((triisopropylsilyl)oxy)cyclopentan-1-ol

: 1591271-14-5
(1R,2S,3S,4R)-2-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-((1R,2S)-1-hydroxy-3-((4-methoxybenzyl)oxy)-2-methylpropyl)-4-methyl-3-((triisopropylsilyl)oxy)cyclopentan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 °C / Inert atmosphere

2.1: 1H-imidazole / Inert atmosphere

2.2: Inert atmosphere

3.1: copper(l) iodide / diethyl ether / 1 h / -78 - 0 °C / Inert atmosphere

3.2: 1 h / -78 °C / Inert atmosphere

4.1: tert.-butyl lithium / pentane; diethyl ether / 0.58 h / -78 - 20 °C / Inert atmosphere

4.2: 5 h / -78 °C / Inert atmosphere

5.1: pyridine; ozone; Sudan III / methanol; dichloromethane / -78 °C / Inert atmosphere

5.2: 12 h / 20 °C / Inert atmosphere

6.1: sodium tetrahydroborate / dichloromethane; ethanol / 24 h / 20 °C / Inert atmosphere

With pyridine; 1H-imidazole; sodium tetrahydroborate; copper(l) iodide; lithium aluminium tetrahydride; tert.-butyl lithium; ozone; Sudan III; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; pentane;
DOI:10.1002/ejoc.201301616