triisopropyl(((4S,5R,6S,7S,8R)-4-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-6-(2-((2-methoxypropan-2-yl)oxy)ethyl)-2,2,8-trimethyl-1,3-dioxaspiro[4.4]nonan-7-yl)oxy)silane

Base Information

Chemical Name:triisopropyl(((4S,5R,6S,7S,8R)-4-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-6-(2-((2-methoxypropan-2-yl)oxy)ethyl)-2,2,8-trimethyl-1,3-dioxaspiro[4.4]nonan-7-yl)oxy)silane
CAS No.:1591271-15-6
Molecular Formula:C₃₆H₆₄O₇Si
Molecular Weight:636.985
Hs Code.:

triisopropyl(((4S,5R,6S,7S,8R)-4-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-6-(2-((2-methoxypropan-2-yl)oxy)ethyl)-2,2,8-trimethyl-1,3-dioxaspiro[4.4]nonan-7-yl)oxy)silane

Synonyms:triisopropyl(((4S,5R,6S,7S,8R)-4-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-6-(2-((2-methoxypropan-2-yl)oxy)ethyl)-2,2,8-trimethyl-1,3-dioxaspiro[4.4]nonan-7-yl)oxy)silane

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Chemical Property of triisopropyl(((4S,5R,6S,7S,8R)-4-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-6-(2-((2-methoxypropan-2-yl)oxy)ethyl)-2,2,8-trimethyl-1,3-dioxaspiro[4.4]nonan-7-yl)oxy)silane

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Technology Process of triisopropyl(((4S,5R,6S,7S,8R)-4-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-6-(2-((2-methoxypropan-2-yl)oxy)ethyl)-2,2,8-trimethyl-1,3-dioxaspiro[4.4]nonan-7-yl)oxy)silane

There total 18 articles about triisopropyl(((4S,5R,6S,7S,8R)-4-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-6-(2-((2-methoxypropan-2-yl)oxy)ethyl)-2,2,8-trimethyl-1,3-dioxaspiro[4.4]nonan-7-yl)oxy)silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1591271-13-4
(1R,2S,3S,4R)-2-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-((1S,2S)-1-hydroxy-3-((4-methoxybenzyl)oxy)-2-methylpropyl)-4-methyl-3-((triisopropylsilyl)oxy)cyclopentan-1-ol

: 77-76-9
2,2-dimethoxy-propane

: 1591271-15-6
triisopropyl(((4S,5R,6S,7S,8R)-4-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-6-(2-((2-methoxypropan-2-yl)oxy)ethyl)-2,2,8-trimethyl-1,3-dioxaspiro[4.4]nonan-7-yl)oxy)silane

Guidance literature:: With pyridinium p-toluenesulfonate; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1002/ejoc.201301616

Reference yield:

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 1591271-15-6
triisopropyl(((4S,5R,6S,7S,8R)-4-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-6-(2-((2-methoxypropan-2-yl)oxy)ethyl)-2,2,8-trimethyl-1,3-dioxaspiro[4.4]nonan-7-yl)oxy)silane

Guidance literature:: Multi-step reaction with 10 steps

1.1: 2,6-dimethylpyridine / dichloromethane / 14 h / 0 °C / Inert atmosphere

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 1 h / Inert atmosphere; Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 °C / Inert atmosphere

4.1: manganese(IV) oxide / dichloromethane / 16 h / 20 °C / Inert atmosphere

5.1: 2,6-dimethylpyridine / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

6.1: copper(l) iodide / diethyl ether / 1 h / -78 - 0 °C / Inert atmosphere

6.2: 1 h / -78 °C / Inert atmosphere

7.1: tert.-butyl lithium / pentane; diethyl ether / 0.58 h / -78 - 20 °C / Inert atmosphere

7.2: 5 h / -78 °C / Inert atmosphere

8.1: pyridine; ozone; Sudan III / methanol; dichloromethane / -78 °C / Inert atmosphere

8.2: 12 h / 20 °C / Inert atmosphere

9.1: sodium tetrahydroborate / dichloromethane; ethanol / 24 h / 20 °C / Inert atmosphere

10.1: pyridinium p-toluenesulfonate / 24 h / 20 °C / Inert atmosphere

With pyridine; 2,6-dimethylpyridine; manganese(IV) oxide; sodium tetrahydroborate; copper(l) iodide; lithium aluminium tetrahydride; tert.-butyl lithium; pyridinium p-toluenesulfonate; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; Sudan III; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; pentane;
DOI:10.1002/ejoc.201301616

Reference yield:

: 1591271-00-9
(3aR,4S,6aR)-4-((triisopropylsilyl)oxy)-3,3a,4,6a-tetrahydro-2H-cyclopenta[b]furan-2-one

: 1591271-15-6
triisopropyl(((4S,5R,6S,7S,8R)-4-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-6-(2-((2-methoxypropan-2-yl)oxy)ethyl)-2,2,8-trimethyl-1,3-dioxaspiro[4.4]nonan-7-yl)oxy)silane

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 °C / Inert atmosphere

2.1: 1H-imidazole / Inert atmosphere

2.2: Inert atmosphere

3.1: copper(l) iodide / diethyl ether / 1 h / -78 - 0 °C / Inert atmosphere

3.2: 1 h / -78 °C / Inert atmosphere

4.1: tert.-butyl lithium / pentane; diethyl ether / 0.58 h / -78 - 20 °C / Inert atmosphere

4.2: 5 h / -78 °C / Inert atmosphere

5.1: pyridine; ozone; Sudan III / methanol; dichloromethane / -78 °C / Inert atmosphere

5.2: 12 h / 20 °C / Inert atmosphere

6.1: sodium tetrahydroborate / dichloromethane; ethanol / 24 h / 20 °C / Inert atmosphere

7.1: pyridinium p-toluenesulfonate / 24 h / 20 °C / Inert atmosphere

With pyridine; 1H-imidazole; sodium tetrahydroborate; copper(l) iodide; lithium aluminium tetrahydride; tert.-butyl lithium; pyridinium p-toluenesulfonate; ozone; Sudan III; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; pentane;
DOI:10.1002/ejoc.201301616