Technology Process of 5-(4-((3-(2,6-dimethylphenyl)phenyl)methoxy)phenyl)isothiazol-3-ol 1,1-dioxide
There total 5 articles about 5-(4-((3-(2,6-dimethylphenyl)phenyl)methoxy)phenyl)isothiazol-3-ol 1,1-dioxide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: thionyl chloride / 3 h / Reflux
2.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 20 °C
3.1: lithium hydroxide monohydrate; water / methanol / 6 h / Reflux
4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C
5.1: ammonium hydroxide / tetrahydrofuran; water / 20 °C / cooling with ice
6.1: sodium monohydrogen sulfide x-hydrate / ethanol / 2 h / Reflux
6.3: 2 h / 20 °C
7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C
With
ammonium hydroxide; thionyl chloride; oxalyl dichloride; sodium monohydrogen sulfide x-hydrate; lithium hydroxide monohydrate; water; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; potassium iodide;
N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 20 °C
2.1: lithium hydroxide monohydrate; water / methanol / 6 h / Reflux
3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C
4.1: ammonium hydroxide / tetrahydrofuran; water / 20 °C / cooling with ice
5.1: sodium monohydrogen sulfide x-hydrate / ethanol / 2 h / Reflux
5.3: 2 h / 20 °C
6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C
With
ammonium hydroxide; oxalyl dichloride; sodium monohydrogen sulfide x-hydrate; lithium hydroxide monohydrate; water; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; potassium iodide;
N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
