(4-chlorophenyl)(3-phenyl-1-oxa-7-azaspiro[4.5]dec-2-en-7-yl)methanone

Base Information

Chemical Name:(4-chlorophenyl)(3-phenyl-1-oxa-7-azaspiro[4.5]dec-2-en-7-yl)methanone
CAS No.:1429122-63-3
Molecular Formula:C₂₁H₂₀ClNO₂
Molecular Weight:353.848
Hs Code.:

Synonyms:(4-chlorophenyl)(3-phenyl-1-oxa-7-azaspiro[4.5]dec-2-en-7-yl)methanone

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Chemical Property of (4-chlorophenyl)(3-phenyl-1-oxa-7-azaspiro[4.5]dec-2-en-7-yl)methanone

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Technology Process of (4-chlorophenyl)(3-phenyl-1-oxa-7-azaspiro[4.5]dec-2-en-7-yl)methanone

There total 6 articles about (4-chlorophenyl)(3-phenyl-1-oxa-7-azaspiro[4.5]dec-2-en-7-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1429122-62-2
tert-butyl 3-phenyl-1-oxa-7-azaspiro[4.5]dec-2-ene-7-carboxylate

: 122-01-0
4-chloro-benzoyl chloride

: 1429122-63-3
(4-chlorophenyl)(3-phenyl-1-oxa-7-azaspiro[4.5]dec-2-en-7-yl)methanone

Guidance literature:: tert-butyl 3-phenyl-1-oxa-7-azaspiro[4.5]dec-2-ene-7-carboxylate; With trifluoroacetic acid; In dichloromethane; for 0.0833333h; Molecular sieve; Inert atmosphere;

4-chloro-benzoyl chloride; With dmap; triethylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jo400077m

Reference yield:

: 98977-36-7
3-oxo-piperidine-1-carboxylic acid tert-butyl ester

: 1429122-63-3
(4-chlorophenyl)(3-phenyl-1-oxa-7-azaspiro[4.5]dec-2-en-7-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: zinc/copper couple / tetrahydrofuran; toluene / 0.17 h / 0 °C / Sonication; Inert atmosphere

1.2: Inert atmosphere

2.1: 3,5-dicholoropyridine N-oxide; methanesulfonic acid / 1,2-dichloro-ethane / Inert atmosphere

2.2: 4 h / Inert atmosphere

3.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

4.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water / N,N-dimethyl-formamide / 1.83 h / 90 °C

5.1: trifluoroacetic acid / dichloromethane / 0.08 h / Molecular sieve; Inert atmosphere

5.2: 2 h / 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; methanesulfonic acid; 3,5-dicholoropyridine N-oxide; zinc/copper couple; water; caesium carbonate; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; 4.1: |Suzuki Coupling;
DOI:10.1021/jo400077m

Reference yield:

: 1429121-56-1
tert-butyl 3-hydroxy-3-(prop-2-yn-1-yl)piperidine-1-carboxylate

: 1429122-63-3
(4-chlorophenyl)(3-phenyl-1-oxa-7-azaspiro[4.5]dec-2-en-7-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: 3,5-dicholoropyridine N-oxide; methanesulfonic acid / 1,2-dichloro-ethane / Inert atmosphere

1.2: 4 h / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

3.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water / N,N-dimethyl-formamide / 1.83 h / 90 °C

4.1: trifluoroacetic acid / dichloromethane / 0.08 h / Molecular sieve; Inert atmosphere

4.2: 2 h / 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; methanesulfonic acid; 3,5-dicholoropyridine N-oxide; water; caesium carbonate; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 3.1: |Suzuki Coupling;
DOI:10.1021/jo400077m