Acetic acid 6,7-dichloro-5-(methyl-phenyl-sulfamoyl)-2,3-dihydro-benzofuran-2-ylmethyl ester

Base Information

• Chemical Name: Acetic acid 6,7-dichloro-5-(methyl-phenyl-sulfamoyl)-2,3-dihydro-benzofuran-2-ylmethyl ester
• CAS No.: 103969-32-0
• Molecular Formula: C₁₈H₁₇Cl₂NO₅S
• Molecular Weight: 430.309

Synonyms:Acetic acid 6,7-dichloro-5-(methyl-phenyl-sulfamoyl)-2,3-dihydro-benzofuran-2-ylmethyl ester

Chemical Property of Acetic acid 6,7-dichloro-5-(methyl-phenyl-sulfamoyl)-2,3-dihydro-benzofuran-2-ylmethyl ester

Chemical Property:

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Technology Process of Acetic acid 6,7-dichloro-5-(methyl-phenyl-sulfamoyl)-2,3-dihydro-benzofuran-2-ylmethyl ester

There total 2 articles about Acetic acid 6,7-dichloro-5-(methyl-phenyl-sulfamoyl)-2,3-dihydro-benzofuran-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6,7-dichloro-2,3-dihydro-2-hydroxymethylbenzofuran (62717-16-2) → Acetic acid 6,7-dichloro-5-(methyl-phenyl-sulfamoyl)-2,3-dihydro-benzofuran-2-ylmethyl ester (103969-32-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / 4-N,N-dimethylaminopyridine / CH₂Cl₂ / 1 h

2: 1.) ClSO₃H / 1.) SOCl₂, room temp., 2 h; 2.) ethanol, CH₂Cl₂, -30 deg C, 2h

With chlorosulfonic acid; dmap; In dichloromethane;

DOI:10.1248/cpb.35.3195

Reference yield:

6,7-dichloro-2,3-dihydrobenzofuran-2-ylmethyl acetate (90247-20-4) + N-methylaniline (100-61-8) → Acetic acid 6,7-dichloro-5-(methyl-phenyl-sulfamoyl)-2,3-dihydro-benzofuran-2-ylmethyl ester (103969-32-0)

Guidance literature:

With chlorosulfonic acid; Yield given. Multistep reaction; 1.) SOCl₂, room temp., 2 h; 2.) ethanol, CH₂Cl₂, -30 deg C, 2h;

DOI:10.1248/cpb.35.3195

Reference yield: 87.0%

Acetic acid 6,7-dichloro-5-(methyl-phenyl-sulfamoyl)-2,3-dihydro-benzofuran-2-ylmethyl ester (103969-32-0) → 6,7-Dichloro-2-hydroxymethyl-2,3-dihydro-benzofuran-5-sulfonic acid methyl-phenyl-amide (103969-39-7)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; for 2h; Ambient temperature;

DOI:10.1248/cpb.35.3195

upstream raw materials:

6,7-dichloro-2,3-dihydrobenzofuran-2-ylmethyl acetate

N-methylaniline

6,7-dichloro-2,3-dihydro-2-hydroxymethylbenzofuran

Downstream raw materials:

6,7-Dichloro-2-hydroxymethyl-2,3-dihydro-benzofuran-5-sulfonic acid methyl-phenyl-amide

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