1-[3-(7-pyridin-3-ylethynylimidazo[1,2-a]pyridin-3-yl)phenyl]-3-(2,2,2-trifluoroethyl)urea

Base Information

Chemical Name:1-[3-(7-pyridin-3-ylethynylimidazo[1,2-a]pyridin-3-yl)phenyl]-3-(2,2,2-trifluoroethyl)urea
CAS No.:1201653-11-3
Molecular Formula:C₂₃H₁₆F₃N₅O
Molecular Weight:435.408
Hs Code.:

Synonyms:1-[3-(7-pyridin-3-ylethynylimidazo[1,2-a]pyridin-3-yl)phenyl]-3-(2,2,2-trifluoroethyl)urea

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Chemical Property of 1-[3-(7-pyridin-3-ylethynylimidazo[1,2-a]pyridin-3-yl)phenyl]-3-(2,2,2-trifluoroethyl)urea

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-[3-(7-pyridin-3-ylethynylimidazo[1,2-a]pyridin-3-yl)phenyl]-3-(2,2,2-trifluoroethyl)urea

There total 8 articles about 1-[3-(7-pyridin-3-ylethynylimidazo[1,2-a]pyridin-3-yl)phenyl]-3-(2,2,2-trifluoroethyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2510-23-8
3-Ethynylpyridine

: 1036986-17-0
1-(3-(7-chloroimidazo[1,2-a]pyridin-3-yl)phenyl)-3-(2,2,2-trifluoroethyl)urea

: 1201653-11-3
1-[3-(7-pyridin-3-ylethynylimidazo[1,2-a]pyridin-3-yl)phenyl]-3-(2,2,2-trifluoroethyl)urea

Guidance literature:: With caesium carbonate; (bis(tricyclohexyl)phosphine)palladium(II) dichloride; In dimethyl sulfoxide; at 120 ℃; for 17h;

Reference yield:

: 19798-80-2
2-Amino-4-chloropyridine

: 1201653-11-3
1-[3-(7-pyridin-3-ylethynylimidazo[1,2-a]pyridin-3-yl)phenyl]-3-(2,2,2-trifluoroethyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / ethanol / 6 h / Reflux

2: N-iodo-succinimide / N,N-dimethyl-formamide / 20 °C

3: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C / Inert atmosphere

4: caesium carbonate / (bis(tricyclohexyl)phosphine)palladium(II) dichloride / dimethyl sulfoxide / 17 h / 120 °C

With potassium phosphate; N-iodo-succinimide; sodium hydrogencarbonate; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; (bis(tricyclohexyl)phosphine)palladium(II) dichloride; In 1,4-dioxane; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; 4: Sonogashira Coupling;

Reference yield:

: 874299-21-5
1-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-3-(2,2,2-trifluoro-ethyl)-urea

: 1201653-11-3
1-[3-(7-pyridin-3-ylethynylimidazo[1,2-a]pyridin-3-yl)phenyl]-3-(2,2,2-trifluoroethyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C / Inert atmosphere

2: caesium carbonate / (bis(tricyclohexyl)phosphine)palladium(II) dichloride / dimethyl sulfoxide / 17 h / 120 °C

With potassium phosphate; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; (bis(tricyclohexyl)phosphine)palladium(II) dichloride; In 1,4-dioxane; dimethyl sulfoxide; 2: Sonogashira Coupling;