1-(3-{7-[2-(3-methyl-3H-imidazol-4-yl)-ethyl]-imidazo[1,2-a]pyridin-3-yl}-phenyl)-3-(2,2,2-trifluoro-ethyl)-urea

Base Information

Chemical Name:1-(3-{7-[2-(3-methyl-3H-imidazol-4-yl)-ethyl]-imidazo[1,2-a]pyridin-3-yl}-phenyl)-3-(2,2,2-trifluoro-ethyl)-urea
CAS No.:1201654-55-8
Molecular Formula:C₂₂H₂₁F₃N₆O
Molecular Weight:442.444
Hs Code.:

Synonyms:1-(3-{7-[2-(3-methyl-3H-imidazol-4-yl)-ethyl]-imidazo[1,2-a]pyridin-3-yl}-phenyl)-3-(2,2,2-trifluoro-ethyl)-urea

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Chemical Property of 1-(3-{7-[2-(3-methyl-3H-imidazol-4-yl)-ethyl]-imidazo[1,2-a]pyridin-3-yl}-phenyl)-3-(2,2,2-trifluoro-ethyl)-urea

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Technology Process of 1-(3-{7-[2-(3-methyl-3H-imidazol-4-yl)-ethyl]-imidazo[1,2-a]pyridin-3-yl}-phenyl)-3-(2,2,2-trifluoro-ethyl)-urea

There total 8 articles about 1-(3-{7-[2-(3-methyl-3H-imidazol-4-yl)-ethyl]-imidazo[1,2-a]pyridin-3-yl}-phenyl)-3-(2,2,2-trifluoro-ethyl)-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1201653-11-3
1-[3-(7-pyridin-3-ylethynylimidazo[1,2-a]pyridin-3-yl)phenyl]-3-(2,2,2-trifluoroethyl)urea

: 1201654-55-8
1-(3-{7-[2-(3-methyl-3H-imidazol-4-yl)-ethyl]-imidazo[1,2-a]pyridin-3-yl}-phenyl)-3-(2,2,2-trifluoro-ethyl)-urea

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; for 7.5h;

Reference yield:

: 19798-80-2
2-Amino-4-chloropyridine

: 1201654-55-8
1-(3-{7-[2-(3-methyl-3H-imidazol-4-yl)-ethyl]-imidazo[1,2-a]pyridin-3-yl}-phenyl)-3-(2,2,2-trifluoro-ethyl)-urea

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / ethanol / 6 h / Reflux

2: N-iodo-succinimide / N,N-dimethyl-formamide / 20 °C

3: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C / Inert atmosphere

4: caesium carbonate / (bis(tricyclohexyl)phosphine)palladium(II) dichloride / dimethyl sulfoxide / 17 h / 120 °C

5: hydrogen / palladium 10% on activated carbon / methanol / 7.5 h

With potassium phosphate; N-iodo-succinimide; hydrogen; sodium hydrogencarbonate; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; (bis(tricyclohexyl)phosphine)palladium(II) dichloride; palladium 10% on activated carbon; In 1,4-dioxane; methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; 4: Sonogashira Coupling;

Reference yield:

: 874299-21-5
1-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-3-(2,2,2-trifluoro-ethyl)-urea

: 1201654-55-8
1-(3-{7-[2-(3-methyl-3H-imidazol-4-yl)-ethyl]-imidazo[1,2-a]pyridin-3-yl}-phenyl)-3-(2,2,2-trifluoro-ethyl)-urea

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C / Inert atmosphere

2: caesium carbonate / (bis(tricyclohexyl)phosphine)palladium(II) dichloride / dimethyl sulfoxide / 17 h / 120 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 7.5 h

With potassium phosphate; hydrogen; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; (bis(tricyclohexyl)phosphine)palladium(II) dichloride; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dimethyl sulfoxide; 2: Sonogashira Coupling;