1-[2-(3,4-dihydro-6-methoxy-2,2,7,8-tetramethyl-2H-1-benzopyran-5-yl)ethyl]-4-(4-nitrophenyl)piperazine

Base Information

Chemical Name:1-[2-(3,4-dihydro-6-methoxy-2,2,7,8-tetramethyl-2H-1-benzopyran-5-yl)ethyl]-4-(4-nitrophenyl)piperazine
CAS No.:910378-79-9
Molecular Formula:C₂₆H₃₅N₃O₄
Molecular Weight:453.582
Hs Code.:

Synonyms:1-[2-(3,4-dihydro-6-methoxy-2,2,7,8-tetramethyl-2H-1-benzopyran-5-yl)ethyl]-4-(4-nitrophenyl)piperazine

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Chemical Property of 1-[2-(3,4-dihydro-6-methoxy-2,2,7,8-tetramethyl-2H-1-benzopyran-5-yl)ethyl]-4-(4-nitrophenyl)piperazine

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Technology Process of 1-[2-(3,4-dihydro-6-methoxy-2,2,7,8-tetramethyl-2H-1-benzopyran-5-yl)ethyl]-4-(4-nitrophenyl)piperazine

There total 3 articles about 1-[2-(3,4-dihydro-6-methoxy-2,2,7,8-tetramethyl-2H-1-benzopyran-5-yl)ethyl]-4-(4-nitrophenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 910378-78-8
3,4-dihydro-6-methoxy-2,2,7,8-tetramethyl-2H-1-benzopyran-5-acetaldehyde

: 6269-89-2
1-(4-Nitrophenyl)piperazine

: 910378-79-9
1-[2-(3,4-dihydro-6-methoxy-2,2,7,8-tetramethyl-2H-1-benzopyran-5-yl)ethyl]-4-(4-nitrophenyl)piperazine

Guidance literature:: 3,4-dihydro-6-methoxy-2,2,7,8-tetramethyl-2H-1-benzopyran-5-acetaldehyde; 1-(4-Nitrophenyl)piperazine; With acetic acid; In acetone; at 0 ℃; for 0.166667h;

With sodium cyanoborohydride; In acetone; at 20 ℃; for 24h;
DOI:10.1016/j.bmc.2006.05.065

Reference yield:

: 586-78-7
para-nitrophenyl bromide

: 910378-79-9
1-[2-(3,4-dihydro-6-methoxy-2,2,7,8-tetramethyl-2H-1-benzopyran-5-yl)ethyl]-4-(4-nitrophenyl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: AcOH / acetone / 0.17 h / 0 °C

1.2: 25 percent / NaBH₃CN / acetone / 24 h / 20 °C

With acetic acid; In acetone;
DOI:10.1016/j.bmc.2006.05.065

Reference yield:

: 389633-98-1
3,4-dihydro-6-methoxy-2,2,7,8-tetramethyl-2H-benzopyran-5-carboxaldehyde

: 910378-79-9
1-[2-(3,4-dihydro-6-methoxy-2,2,7,8-tetramethyl-2H-1-benzopyran-5-yl)ethyl]-4-(4-nitrophenyl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: tert-BuOK / tetrahydrofuran / 0.25 h / 0 °C

1.2: tetrahydrofuran / 24 h / 20 °C

1.3: 0.310 g / p-toluenesulfonic acid / H₂O; dioxane / 24 h / Heating

2.1: AcOH / acetone / 0.17 h / 0 °C

2.2: 25 percent / NaBH₃CN / acetone / 24 h / 20 °C

With potassium tert-butylate; acetic acid; In tetrahydrofuran; acetone;
DOI:10.1016/j.bmc.2006.05.065