4-[4-[2-(3,4-dihydro-6-methoxy-2,2,7,8-tetramethyl-2H-1-benzopyran-5-yl)ethyl]piperazin-1-yl]aniline

Base Information

• Chemical Name: 4-[4-[2-(3,4-dihydro-6-methoxy-2,2,7,8-tetramethyl-2H-1-benzopyran-5-yl)ethyl]piperazin-1-yl]aniline
• CAS No.: 910378-80-2
• Molecular Formula: C₂₆H₃₇N₃O₂
• Molecular Weight: 423.599

Synonyms:4-[4-[2-(3,4-dihydro-6-methoxy-2,2,7,8-tetramethyl-2H-1-benzopyran-5-yl)ethyl]piperazin-1-yl]aniline

Chemical Property of 4-[4-[2-(3,4-dihydro-6-methoxy-2,2,7,8-tetramethyl-2H-1-benzopyran-5-yl)ethyl]piperazin-1-yl]aniline

Chemical Property:

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Technology Process of 4-[4-[2-(3,4-dihydro-6-methoxy-2,2,7,8-tetramethyl-2H-1-benzopyran-5-yl)ethyl]piperazin-1-yl]aniline

There total 5 articles about 4-[4-[2-(3,4-dihydro-6-methoxy-2,2,7,8-tetramethyl-2H-1-benzopyran-5-yl)ethyl]piperazin-1-yl]aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-[2-(3,4-dihydro-6-methoxy-2,2,7,8-tetramethyl-2H-1-benzopyran-5-yl)ethyl]-4-(4-nitrophenyl)piperazine (910378-79-9) → 4-[4-[2-(3,4-dihydro-6-methoxy-2,2,7,8-tetramethyl-2H-1-benzopyran-5-yl)ethyl]piperazin-1-yl]aniline (910378-80-2)

Guidance literature:

With sodium tetrahydroborate; copper(l) chloride; In ethanol; for 2h; Heating;

DOI:10.1016/j.bmc.2006.05.065

Reference yield:

3,4-dihydro-6-methoxy-2,2,7,8-tetramethyl-2H-1-benzopyran-5-acetaldehyde (910378-78-8) → 4-[4-[2-(3,4-dihydro-6-methoxy-2,2,7,8-tetramethyl-2H-1-benzopyran-5-yl)ethyl]piperazin-1-yl]aniline (910378-80-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: AcOH / acetone / 0.17 h / 0 °C

1.2: 25 percent / NaBH₃CN / acetone / 24 h / 20 °C

2.1: 98 percent / NaBH₄; CuCl / ethanol / 2 h / Heating

With sodium tetrahydroborate; acetic acid; copper(l) chloride; In ethanol; acetone;

DOI:10.1016/j.bmc.2006.05.065

Reference yield:

1-(4-Nitrophenyl)piperazine (6269-89-2) → 4-[4-[2-(3,4-dihydro-6-methoxy-2,2,7,8-tetramethyl-2H-1-benzopyran-5-yl)ethyl]piperazin-1-yl]aniline (910378-80-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: AcOH / acetone / 0.17 h / 0 °C

1.2: 25 percent / NaBH₃CN / acetone / 24 h / 20 °C

2.1: 98 percent / NaBH₄; CuCl / ethanol / 2 h / Heating

With sodium tetrahydroborate; acetic acid; copper(l) chloride; In ethanol; acetone;

DOI:10.1016/j.bmc.2006.05.065

upstream raw materials:

1-[2-(3,4-dihydro-6-methoxy-2,2,7,8-tetramethyl-2H-1-benzopyran-5-yl)ethyl]-4-(4-nitrophenyl)piperazine

3,4-dihydro-6-methoxy-2,2,7,8-tetramethyl-2H-1-benzopyran-5-acetaldehyde

1-(4-Nitrophenyl)piperazine

para-nitrophenyl bromide

Downstream raw materials:

N-[4-[4-[2-(3,4-dihydro-6-methoxy-2,2,7,8-tetramethyl-2H-1-benzopyran-5-yl)ethyl]piperazin-1-yl]phenyl]methanesulfonamide

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