5-[methyl-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-yl)-carbamoyl]-isophthalic acid

Base Information

Chemical Name:5-[methyl-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-yl)-carbamoyl]-isophthalic acid
CAS No.:304682-09-5
Molecular Formula:C₂₄H₂₇NO₁₀
Molecular Weight:489.479
Hs Code.:

Synonyms:5-[methyl-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-yl)-carbamoyl]-isophthalic acid

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Chemical Property of 5-[methyl-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-yl)-carbamoyl]-isophthalic acid

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Technology Process of 5-[methyl-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-yl)-carbamoyl]-isophthalic acid

There total 4 articles about 5-[methyl-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-yl)-carbamoyl]-isophthalic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 304682-08-4
5-[methyl-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-yl)-carbamoyl]-isophthalic acid dimethyl ester

: 304682-09-5
5-[methyl-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-yl)-carbamoyl]-isophthalic acid

Guidance literature:: With potassium hydroxide; In methanol; water; for 14h;
DOI:10.1021/ol0063104

Reference yield:

: 304682-07-3
5-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-ylcarbamoyl)-isophthalic acid dimethyl ester

: 304682-09-5
5-[methyl-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-yl)-carbamoyl]-isophthalic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / NaH / tetrahydrofuran; dimethylformamide / 8 h / 100 °C

2: 56 percent / KOH / methanol; H₂O / 14 h

With potassium hydroxide; sodium hydride; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; 1: Methylation / 2: Hydrolysis;
DOI:10.1021/ol0063104

Reference yield:

: 60835-71-4
4'-aminobenzo-15-crown-5-ether

: 304682-09-5
5-[methyl-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-yl)-carbamoyl]-isophthalic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-(dimethylamino)pyridine; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl; 1-hydroxy-7-azabenzotriazole / acetonitrile / 0.5 h / 0 - 5 °C

1.2: 59 percent / acetonitrile / 6 h / 20 °C

2.1: 71 percent / NaH / tetrahydrofuran; dimethylformamide / 8 h / 100 °C

3.1: 56 percent / KOH / methanol; H₂O / 14 h

With dmap; potassium hydroxide; 1-hydroxy-7-aza-benzotriazole; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile; 1.1: Addition / 1.2: Addition / 2.1: Methylation / 3.1: Hydrolysis;
DOI:10.1021/ol0063104