5-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-ylcarbamoyl)-isophthalic acid dimethyl ester

Base Information

Chemical Name:5-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-ylcarbamoyl)-isophthalic acid dimethyl ester
CAS No.:304682-07-3
Molecular Formula:C₂₅H₂₉NO₁₀
Molecular Weight:503.506
Hs Code.:

Synonyms:5-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-ylcarbamoyl)-isophthalic acid dimethyl ester

Suppliers and Price of 5-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-ylcarbamoyl)-isophthalic acid dimethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-ylcarbamoyl)-isophthalic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-ylcarbamoyl)-isophthalic acid dimethyl ester

There total 1 articles about 5-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-ylcarbamoyl)-isophthalic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 60835-71-4
4'-aminobenzo-15-crown-5-ether

: 38588-64-6
3,5-bis(methoxycarbonyl)benzoic acid

: 304682-07-3
5-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-ylcarbamoyl)-isophthalic acid dimethyl ester

Guidance literature:: 3,5-bis(methoxycarbonyl)benzoic acid; With dmap; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 0 - 5 ℃; for 0.5h;

4'-aminobenzo-15-crown-5-ether; In acetonitrile; at 20 ℃; for 6h; Further stages.;
DOI:10.1021/ol0063104

Reference yield: 71.0%

: 304682-07-3
5-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-ylcarbamoyl)-isophthalic acid dimethyl ester

: 74-88-4
methyl iodide

: 304682-08-4
5-[methyl-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-yl)-carbamoyl]-isophthalic acid dimethyl ester

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 100 ℃; for 8h;
DOI:10.1021/ol0063104

Reference yield:

: 304682-07-3
5-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-ylcarbamoyl)-isophthalic acid dimethyl ester

: benzene-1,3,5-tricarboxylic acid 1-[methyl-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-yl)-amide] 3,5-bis-p-tolylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 71 percent / NaH / tetrahydrofuran; dimethylformamide / 8 h / 100 °C

2.1: 56 percent / KOH / methanol; H₂O / 14 h

3.1: 4-(dimethylamino)pyridine; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl; 1-hydroxy-7-azabenzotriazole / dimethylformamide / 1 h / cooling

3.2: 44 percent / dimethylformamide / 12 h / 20 °C

With dmap; potassium hydroxide; 1-hydroxy-7-aza-benzotriazole; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; 1.1: Methylation / 2.1: Hydrolysis / 3.1: Addition / 3.2: Addition;
DOI:10.1021/ol0063104