Technology Process of 5-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-ylcarbamoyl)-isophthalic acid dimethyl ester
There total 1 articles about 5-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-ylcarbamoyl)-isophthalic acid dimethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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304682-07-3
5-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-ylcarbamoyl)-isophthalic acid dimethyl ester
- Guidance literature:
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3,5-bis(methoxycarbonyl)benzoic acid;
With
dmap; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
acetonitrile;
at 0 - 5 ℃;
for 0.5h;
4'-aminobenzo-15-crown-5-ether;
In
acetonitrile;
at 20 ℃;
for 6h;
Further stages.;
DOI:10.1021/ol0063104
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304682-07-3
5-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-ylcarbamoyl)-isophthalic acid dimethyl ester
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304682-08-4
5-[methyl-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-yl)-carbamoyl]-isophthalic acid dimethyl ester
- Guidance literature:
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With
sodium hydride;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at 100 ℃;
for 8h;
DOI:10.1021/ol0063104
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304682-07-3
5-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-ylcarbamoyl)-isophthalic acid dimethyl ester
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benzene-1,3,5-tricarboxylic acid 1-[methyl-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-yl)-amide] 3,5-bis-p-tolylamide
- Guidance literature:
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Multi-step reaction with 3 steps
1.1: 71 percent / NaH / tetrahydrofuran; dimethylformamide / 8 h / 100 °C
2.1: 56 percent / KOH / methanol; H2O / 14 h
3.1: 4-(dimethylamino)pyridine; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl; 1-hydroxy-7-azabenzotriazole / dimethylformamide / 1 h / cooling
3.2: 44 percent / dimethylformamide / 12 h / 20 °C
With
dmap; potassium hydroxide; 1-hydroxy-7-aza-benzotriazole; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
1.1: Methylation / 2.1: Hydrolysis / 3.1: Addition / 3.2: Addition;
DOI:10.1021/ol0063104