cis-2-bromo-N-[4-(4-dimethylamino-5-methyl-pyrimidin-2-ylamino)-cyclohexyl]-acetamide

Base Information

• Chemical Name: cis-2-bromo-N-[4-(4-dimethylamino-5-methyl-pyrimidin-2-ylamino)-cyclohexyl]-acetamide
• CAS No.: 771545-70-1
• Molecular Formula: C₁₅H₂₄BrN₅O
• Molecular Weight: 370.292
• Mol file: 771545-70-1.mol

Synonyms:cis-2-bromo-N-[4-(4-dimethylamino-5-methyl-pyrimidin-2-ylamino)-cyclohexyl]-acetamide

Chemical Property of cis-2-bromo-N-[4-(4-dimethylamino-5-methyl-pyrimidin-2-ylamino)-cyclohexyl]-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-2-bromo-N-[4-(4-dimethylamino-5-methyl-pyrimidin-2-ylamino)-cyclohexyl]-acetamide

There total 2 articles about cis-2-bromo-N-[4-(4-dimethylamino-5-methyl-pyrimidin-2-ylamino)-cyclohexyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

cis-[4-(4-dimethylamino-5-methyl-pyrimidin-2-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester (771543-90-9) + 2-Bromoacetyl bromide (598-21-0) → cis-2-bromo-N-[4-(4-dimethylamino-5-methyl-pyrimidin-2-ylamino)-cyclohexyl]-acetamide (771545-70-1)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 0.166667h;

Reference yield:

cis-4-(4-dimethylamino-5-methyl-pyrimidin-2-ylamino)-4-aminocyclohexane (771543-91-0) + 2-Bromoacetyl bromide (598-21-0) → cis-2-bromo-N-[4-(4-dimethylamino-5-methyl-pyrimidin-2-ylamino)-cyclohexyl]-acetamide (771545-70-1)

Guidance literature:

cis-4-(4-dimethylamino-5-methyl-pyrimidin-2-ylamino)-4-aminocyclohexane; 2-Bromoacetyl bromide; In DCM; at 0 ℃; for 0.0833333h;

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 15 ℃; for 3h;

Reference yield: 34.0%

cis-2-bromo-N-[4-(4-dimethylamino-5-methyl-pyrimidin-2-ylamino)-cyclohexyl]-acetamide (771545-70-1) + 3-fluorophenol (372-20-3) → N-(cis-4-{[4-(dimethylamino)-5-methylpyrimidin-2-yl]amino}cyclohexyl)-2-(3-fluorophenoxy)acetamide

Guidance literature:

With caesium carbonate; In 1,4-dioxane; at 180 ℃; for 0.833333h; Irradiation;

upstream raw materials:

cis-4-(4-dimethylamino-5-methyl-pyrimidin-2-ylamino)-4-aminocyclohexane

2-Bromoacetyl bromide

cis-[4-(4-dimethylamino-5-methyl-pyrimidin-2-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester