(E)-1-[4-chloro-6-methoxy-2-(methylsulfanyl)pyrimidin-5-yl]-3-phenylprop-2-en-1-ol

Base Information

Chemical Name:(E)-1-[4-chloro-6-methoxy-2-(methylsulfanyl)pyrimidin-5-yl]-3-phenylprop-2-en-1-ol
CAS No.:1449464-76-9
Molecular Formula:C₁₅H₁₅ClN₂O₂S
Molecular Weight:322.815
Hs Code.:

Synonyms:(E)-1-[4-chloro-6-methoxy-2-(methylsulfanyl)pyrimidin-5-yl]-3-phenylprop-2-en-1-ol

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Chemical Property of (E)-1-[4-chloro-6-methoxy-2-(methylsulfanyl)pyrimidin-5-yl]-3-phenylprop-2-en-1-ol

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Technology Process of (E)-1-[4-chloro-6-methoxy-2-(methylsulfanyl)pyrimidin-5-yl]-3-phenylprop-2-en-1-ol

There total 1 articles about (E)-1-[4-chloro-6-methoxy-2-(methylsulfanyl)pyrimidin-5-yl]-3-phenylprop-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 14371-10-9
(E)-3-phenylpropenal

: 89466-42-2
4-chloro-6-methoxy-2-(methylsulfanyl)pyrimidine

: 1449464-76-9
(E)-1-[4-chloro-6-methoxy-2-(methylsulfanyl)pyrimidin-5-yl]-3-phenylprop-2-en-1-ol

Guidance literature:: 4-chloro-6-methoxy-2-(methylsulfanyl)pyrimidine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1.5h;

(E)-3-phenylpropenal; In tetrahydrofuran; at -78 ℃; for 0.5h;
DOI:10.3987/COM-13-12677

Reference yield: 90.0%

: 1449464-76-9
(E)-1-[4-chloro-6-methoxy-2-(methylsulfanyl)pyrimidin-5-yl]-3-phenylprop-2-en-1-ol

: 75-66-1
2-methylpropan-2-thiol

: 1449464-86-1
(E)-1-[4-(1,1-dimethylethylsulfanyl)-6-methoxy-2-(methylsulfanyl)pyrimidin-5-yl]-3-phenylprop-2-en-1-ol

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at -20 - -10 ℃; for 0.5h;
DOI:10.3987/COM-13-12677

Reference yield:

: 1449464-76-9
(E)-1-[4-chloro-6-methoxy-2-(methylsulfanyl)pyrimidin-5-yl]-3-phenylprop-2-en-1-ol

: 1449464-96-3
4-methoxy-2-methylsulfanyl-7-phenyl-7H-thiopyrano[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.5 h / -20 - -10 °C

2: hydrogen bromide / acetonitrile / 0 °C

With hydrogen bromide; sodium hydride; In N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.3987/COM-13-12677