2-(3-(1-hydroxybutan-2-yloxy)-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidin-4(3H)-one

Base Information

Chemical Name:2-(3-(1-hydroxybutan-2-yloxy)-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidin-4(3H)-one
CAS No.:1352570-42-3
Molecular Formula:C₂₁H₂₂N₂O₆S
Molecular Weight:430.481
Hs Code.:

Synonyms:2-(3-(1-hydroxybutan-2-yloxy)-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidin-4(3H)-one

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Chemical Property of 2-(3-(1-hydroxybutan-2-yloxy)-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidin-4(3H)-one

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Technology Process of 2-(3-(1-hydroxybutan-2-yloxy)-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidin-4(3H)-one

There total 4 articles about 2-(3-(1-hydroxybutan-2-yloxy)-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₅H₄₄N₂O₇SSi

: 1352570-42-3
2-(3-(1-hydroxybutan-2-yloxy)-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidin-4(3H)-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 1352571-59-5
C₃₀H₄₄N₂O₄Si₂

: 1352570-42-3
2-(3-(1-hydroxybutan-2-yloxy)-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 120 °C / Sealed tube

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

4: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; potassium carbonate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3: Mitsunobu reaction;

Reference yield:

: 1352570-99-0
5-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)benzene-1,3-diol

: 1352570-42-3
2-(3-(1-hydroxybutan-2-yloxy)-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 120 °C / Sealed tube

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

3: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2: Mitsunobu reaction;