3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenol

Base Information

Chemical Name:3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenol
CAS No.:1352571-31-3
Molecular Formula:C₂₅H₂₂N₂O₆S
Molecular Weight:478.525
Hs Code.:

Synonyms:3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenol

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Chemical Property of 3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenol

Chemical Property:

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Technology Process of 3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenol

There total 4 articles about 3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 455-15-2
1-(methylsufonyl)-4-fluorobenzene

: 1352570-99-0
5-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)benzene-1,3-diol

: 1352571-31-3
3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenol

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; Sealed tube;

Reference yield:

: 105-13-5
4-Methoxybenzyl alcohol

: 1352571-31-3
3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium t-butanolate / tetrahydrofuran / 1 h / Reflux

1.2: 2 h / -70 - 20 °C

2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 70 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 120 °C / Sealed tube

With tetrabutyl ammonium fluoride; sodium carbonate; potassium carbonate; sodium t-butanolate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 2.1: Suzuki Coupling;

Reference yield:

: 480998-38-7
2-chloro-4-((4-methoxybenzyl)oxy)pyrimidine

: 1352571-31-3
3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 70 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 120 °C / Sealed tube

With tetrabutyl ammonium fluoride; sodium carbonate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 1: Suzuki Coupling;