1-[4,6-dibromo-2-(2-chloro-phenyl)-pyridin-3-ylmethyl]-3-(2,6-dichloro-phenyl)-1-(4-methoxy-benzyl)-urea

Base Information

Chemical Name:1-[4,6-dibromo-2-(2-chloro-phenyl)-pyridin-3-ylmethyl]-3-(2,6-dichloro-phenyl)-1-(4-methoxy-benzyl)-urea
CAS No.:906463-09-0
Molecular Formula:C₂₇H₂₀Br₂Cl₃N₃O₂
Molecular Weight:684.642
Hs Code.:

Synonyms:1-[4,6-dibromo-2-(2-chloro-phenyl)-pyridin-3-ylmethyl]-3-(2,6-dichloro-phenyl)-1-(4-methoxy-benzyl)-urea

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Chemical Property of 1-[4,6-dibromo-2-(2-chloro-phenyl)-pyridin-3-ylmethyl]-3-(2,6-dichloro-phenyl)-1-(4-methoxy-benzyl)-urea

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Technology Process of 1-[4,6-dibromo-2-(2-chloro-phenyl)-pyridin-3-ylmethyl]-3-(2,6-dichloro-phenyl)-1-(4-methoxy-benzyl)-urea

There total 8 articles about 1-[4,6-dibromo-2-(2-chloro-phenyl)-pyridin-3-ylmethyl]-3-(2,6-dichloro-phenyl)-1-(4-methoxy-benzyl)-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 906463-08-9
[4,6-dibromo-2-(2-chloro-phenyl)-pyridin-3-ylmethyl]-(4-methoxy-benzyl)-amine

: 39920-37-1
2,6-dichlorophenylisocyanate

: 906463-09-0
1-[4,6-dibromo-2-(2-chloro-phenyl)-pyridin-3-ylmethyl]-3-(2,6-dichloro-phenyl)-1-(4-methoxy-benzyl)-urea

Guidance literature:: DOI:10.1016/j.bmcl.2006.05.045

Reference yield:

: 22280-56-4
2-chloro-3-methyl-5-nitropyridine

: 906463-09-0
1-[4,6-dibromo-2-(2-chloro-phenyl)-pyridin-3-ylmethyl]-3-(2,6-dichloro-phenyl)-1-(4-methoxy-benzyl)-urea

Guidance literature:: Multi-step reaction with 7 steps

1: 88 percent / aq. Cs₂CO₃; Pd(PPh₃)4 / toluene; methanol / 12 h / Heating

2: 85 percent / Raney Ni / methanol / 7 h / 20 °C

3: 85 percent / Br₂; aq. HCl / tetrahydrofuran / 2 h

4: 80 percent / i-amylONO / tetrahydrofuran / 1 h / Heating

5: 85 percent / NBS; Bz₂O₂ / CCl₄ / 95 °C

6: 75 percent / CH₂Cl₂ / 20 °C

With hydrogenchloride; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; nickel; caesium carbonate; isopentyl nitrite; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; toluene; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2006.05.045

Reference yield:

: 3900-89-8
2-Chlorobenzeneboronic acid

: 906463-09-0
1-[4,6-dibromo-2-(2-chloro-phenyl)-pyridin-3-ylmethyl]-3-(2,6-dichloro-phenyl)-1-(4-methoxy-benzyl)-urea

Guidance literature:: Multi-step reaction with 7 steps

1: 88 percent / aq. Cs₂CO₃; Pd(PPh₃)4 / toluene; methanol / 12 h / Heating

2: 85 percent / Raney Ni / methanol / 7 h / 20 °C

3: 85 percent / Br₂; aq. HCl / tetrahydrofuran / 2 h

4: 80 percent / i-amylONO / tetrahydrofuran / 1 h / Heating

5: 85 percent / NBS; Bz₂O₂ / CCl₄ / 95 °C

6: 75 percent / CH₂Cl₂ / 20 °C

With hydrogenchloride; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; nickel; caesium carbonate; isopentyl nitrite; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; toluene; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2006.05.045