6-bromo-3-[1-(2,6-dichloro-3-fluorophenyl)ethyl]-3H,4H-pyrido[2,3-d]pyrimidin-4-one

Base Information

Chemical Name:6-bromo-3-[1-(2,6-dichloro-3-fluorophenyl)ethyl]-3H,4H-pyrido[2,3-d]pyrimidin-4-one
CAS No.:1394930-38-1
Molecular Formula:C₁₅H₉BrCl₂FN₃O
Molecular Weight:417.064
Hs Code.:

Synonyms:6-bromo-3-[1-(2,6-dichloro-3-fluorophenyl)ethyl]-3H,4H-pyrido[2,3-d]pyrimidin-4-one

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Chemical Property of 6-bromo-3-[1-(2,6-dichloro-3-fluorophenyl)ethyl]-3H,4H-pyrido[2,3-d]pyrimidin-4-one

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Technology Process of 6-bromo-3-[1-(2,6-dichloro-3-fluorophenyl)ethyl]-3H,4H-pyrido[2,3-d]pyrimidin-4-one

There total 4 articles about 6-bromo-3-[1-(2,6-dichloro-3-fluorophenyl)ethyl]-3H,4H-pyrido[2,3-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 155690-79-2
6-bromo-3H,4H-pyrido[2,3-d]pyrimidin-4-one

: 1229457-91-3
1-(2,6-dichloro-3-fluorophenyl)ethyl methanesulfonate

: 1394930-38-1
6-bromo-3-[1-(2,6-dichloro-3-fluorophenyl)ethyl]-3H,4H-pyrido[2,3-d]pyrimidin-4-one

Guidance literature:: 6-bromo-3H,4H-pyrido[2,3-d]pyrimidin-4-one; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃;

1-(2,6-dichloro-3-fluorophenyl)ethyl methanesulfonate; In N,N-dimethyl-formamide; mineral oil; at 80 ℃; for 4h;
DOI:10.1016/j.bmc.2012.07.007

Reference yield:

: 5345-47-1
2-aminopyridin-3-carboxylic acid

: 1394930-38-1
6-bromo-3-[1-(2,6-dichloro-3-fluorophenyl)ethyl]-3H,4H-pyrido[2,3-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; bromine / 0.5 h / 20 °C

2.1: 0.5 h / 150 °C / Microwave irradiation

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C

3.2: 4 h / 80 °C

With bromine; sodium hydride; acetic acid; In N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2012.07.007

Reference yield:

: 290835-85-7
2',6'-dichloro-3'-fluoroacetophenone

: 1394930-38-1
6-bromo-3-[1-(2,6-dichloro-3-fluorophenyl)ethyl]-3H,4H-pyrido[2,3-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate / methanol / 2 h / 20 °C

2.1: triethylamine; dmap / dichloromethane / 1 h / 0 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C

3.2: 4 h / 80 °C

With dmap; sodium tetrahydroborate; sodium hydride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2012.07.007