2-Methylamino-benzoic acid (2E,6E,10E)-12-((R)-2-amino-2-methoxycarbonyl-ethylsulfanyl)-2,6,10-trimethyl-dodeca-2,6,10-trienyl ester

Base Information

Chemical Name:2-Methylamino-benzoic acid (2E,6E,10E)-12-((R)-2-amino-2-methoxycarbonyl-ethylsulfanyl)-2,6,10-trimethyl-dodeca-2,6,10-trienyl ester
CAS No.:330641-23-1
Molecular Formula:C₂₇H₄₀N₂O₄S
Molecular Weight:488.692
Hs Code.:

Synonyms:2-Methylamino-benzoic acid (2E,6E,10E)-12-((R)-2-amino-2-methoxycarbonyl-ethylsulfanyl)-2,6,10-trimethyl-dodeca-2,6,10-trienyl ester

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Chemical Property of 2-Methylamino-benzoic acid (2E,6E,10E)-12-((R)-2-amino-2-methoxycarbonyl-ethylsulfanyl)-2,6,10-trimethyl-dodeca-2,6,10-trienyl ester

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Technology Process of 2-Methylamino-benzoic acid (2E,6E,10E)-12-((R)-2-amino-2-methoxycarbonyl-ethylsulfanyl)-2,6,10-trimethyl-dodeca-2,6,10-trienyl ester

There total 5 articles about 2-Methylamino-benzoic acid (2E,6E,10E)-12-((R)-2-amino-2-methoxycarbonyl-ethylsulfanyl)-2,6,10-trimethyl-dodeca-2,6,10-trienyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 18598-63-5
L-cysteine methyl ester hydrochloride

: 330641-21-9
2-Methylamino-benzoic acid (2E,6E,10E)-12-chloro-2,6,10-trimethyl-dodeca-2,6,10-trienyl ester

: 330641-23-1
2-Methylamino-benzoic acid (2E,6E,10E)-12-((R)-2-amino-2-methoxycarbonyl-ethylsulfanyl)-2,6,10-trimethyl-dodeca-2,6,10-trienyl ester

Guidance literature:: In tetrahydrofuran; ammonia; at -40 - 20 ℃;
DOI:10.1021/ja002723o

Reference yield:

: 10328-92-4
N-Methylisatoic anhydride

: 330641-23-1
2-Methylamino-benzoic acid (2E,6E,10E)-12-((R)-2-amino-2-methoxycarbonyl-ethylsulfanyl)-2,6,10-trimethyl-dodeca-2,6,10-trienyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 66 percent / DMAP; Et₃N / dimethylformamide / 65 °C

2: 92 percent / PPTS / ethanol / 60 °C

3: 92 percent / N-chlorosuccinimide; Me₂S / CH₂Cl₂ / -40 - 20 °C

4: 95 percent / tetrahydrofuran; liquid ammonia / -40 - 20 °C

With dmap; N-chloro-succinimide; dimethylsulfide; pyridinium p-toluenesulfonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; ammonia; N,N-dimethyl-formamide;
DOI:10.1021/ja002723o

Reference yield:

: 101972-88-7
(2E,6E,10E)-2,6,10-trimethyl-12-((tetrahydro-2H-pyran-2-yl)oxy)dodeca-2,6,10-trien-1-ol

: 330641-23-1
2-Methylamino-benzoic acid (2E,6E,10E)-12-((R)-2-amino-2-methoxycarbonyl-ethylsulfanyl)-2,6,10-trimethyl-dodeca-2,6,10-trienyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 66 percent / DMAP; Et₃N / dimethylformamide / 65 °C

2: 92 percent / PPTS / ethanol / 60 °C

3: 92 percent / N-chlorosuccinimide; Me₂S / CH₂Cl₂ / -40 - 20 °C

4: 95 percent / tetrahydrofuran; liquid ammonia / -40 - 20 °C

With dmap; N-chloro-succinimide; dimethylsulfide; pyridinium p-toluenesulfonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; ammonia; N,N-dimethyl-formamide;
DOI:10.1021/ja002723o