2-methylamino-benzoic acid 12-{2-[(1-{2-[2-(2-amino-4-methylsulfanyl-butyrylamino)-acetylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carbonyl)-amino]-2-methoxycarbonyl-ethylsulfanyl}-2,6,10-trimethyl-dodeca-2,6,10-trienyl ester

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Chemical Name:2-methylamino-benzoic acid 12-{2-[(1-{2-[2-(2-amino-4-methylsulfanyl-butyrylamino)-acetylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carbonyl)-amino]-2-methoxycarbonyl-ethylsulfanyl}-2,6,10-trimethyl-dodeca-2,6,10-trienyl ester
CAS No.:330641-34-4
Molecular Formula:C₄₅H₇₀N₆O₈S₂
Molecular Weight:887.218
Hs Code.:

2-methylamino-benzoic acid 12-{2-[(1-{2-[2-(2-amino-4-methylsulfanyl-butyrylamino)-acetylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carbonyl)-amino]-2-methoxycarbonyl-ethylsulfanyl}-2,6,10-trimethyl-dodeca-2,6,10-trienyl ester

Synonyms:2-methylamino-benzoic acid 12-{2-[(1-{2-[2-(2-amino-4-methylsulfanyl-butyrylamino)-acetylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carbonyl)-amino]-2-methoxycarbonyl-ethylsulfanyl}-2,6,10-trimethyl-dodeca-2,6,10-trienyl ester

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Chemical Property of 2-methylamino-benzoic acid 12-{2-[(1-{2-[2-(2-amino-4-methylsulfanyl-butyrylamino)-acetylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carbonyl)-amino]-2-methoxycarbonyl-ethylsulfanyl}-2,6,10-trimethyl-dodeca-2,6,10-trienyl ester

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Technology Process of 2-methylamino-benzoic acid 12-{2-[(1-{2-[2-(2-amino-4-methylsulfanyl-butyrylamino)-acetylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carbonyl)-amino]-2-methoxycarbonyl-ethylsulfanyl}-2,6,10-trimethyl-dodeca-2,6,10-trienyl ester

There total 12 articles about 2-methylamino-benzoic acid 12-{2-[(1-{2-[2-(2-amino-4-methylsulfanyl-butyrylamino)-acetylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carbonyl)-amino]-2-methoxycarbonyl-ethylsulfanyl}-2,6,10-trimethyl-dodeca-2,6,10-trienyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 330641-31-1
C₆₀H₈₀N₆O₁₀S₂

: 330641-34-4
2-methylamino-benzoic acid 12-{2-[(1-{2-[2-(2-amino-4-methylsulfanyl-butyrylamino)-acetylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carbonyl)-amino]-2-methoxycarbonyl-ethylsulfanyl}-2,6,10-trimethyl-dodeca-2,6,10-trienyl ester

Guidance literature:: With piperidine; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1021/ja002723o

Reference yield:

: 10328-92-4
N-Methylisatoic anhydride

: 330641-34-4
2-methylamino-benzoic acid 12-{2-[(1-{2-[2-(2-amino-4-methylsulfanyl-butyrylamino)-acetylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carbonyl)-amino]-2-methoxycarbonyl-ethylsulfanyl}-2,6,10-trimethyl-dodeca-2,6,10-trienyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 66 percent / DMAP; Et₃N / dimethylformamide / 65 °C

2: 92 percent / PPTS / ethanol / 60 °C

3: 92 percent / N-chlorosuccinimide; Me₂S / CH₂Cl₂ / -40 - 20 °C

4: 95 percent / tetrahydrofuran; liquid ammonia / -40 - 20 °C

5: 63 percent / HOBt; EDC / CH₂Cl₂ / 18 h / 20 °C

6: 94 percent / piperidine / CH₂Cl₂ / 18 h / 20 °C

With piperidine; dmap; N-chloro-succinimide; dimethylsulfide; pyridinium p-toluenesulfonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; ammonia; N,N-dimethyl-formamide;
DOI:10.1021/ja002723o

Reference yield:

: 71989-28-1
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

: 330641-34-4
2-methylamino-benzoic acid 12-{2-[(1-{2-[2-(2-amino-4-methylsulfanyl-butyrylamino)-acetylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carbonyl)-amino]-2-methoxycarbonyl-ethylsulfanyl}-2,6,10-trimethyl-dodeca-2,6,10-trienyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: HOBt; dicyclohexylcarbodiimide / tetrahydrofuran / 1 h / 0 °C

1.2: 60 percent / triethylamine / tetrahydrofuran / 24 h

2.1: dimethylbarbituric acid; tetrakis(triphenylphosphine)palladium⁽⁰⁾ / tetrahydrofuran

3.1: 84 percent / HOBt; EDC; triethylamine / CH₂Cl₂ / 18 h / 20 °C

4.1: 88 percent / dimethylbarbituric acid; tetrakis(triphenylphosphine)palladium⁽⁰⁾ / tetrahydrofuran

5.1: 63 percent / HOBt; EDC / CH₂Cl₂ / 18 h / 20 °C

6.1: 94 percent / piperidine / CH₂Cl₂ / 18 h / 20 °C

With piperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja002723o