(2R,4R)-1-(p-methoxybenzyloxy)-6-(triisopropylsilanyloxy)hexane-2,4-diol

Base Information

Chemical Name:(2R,4R)-1-(p-methoxybenzyloxy)-6-(triisopropylsilanyloxy)hexane-2,4-diol
CAS No.:638222-37-4
Molecular Formula:C₂₃H₄₂O₅Si
Molecular Weight:426.669
Hs Code.:

Synonyms:(2R,4R)-1-(p-methoxybenzyloxy)-6-(triisopropylsilanyloxy)hexane-2,4-diol

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Chemical Property of (2R,4R)-1-(p-methoxybenzyloxy)-6-(triisopropylsilanyloxy)hexane-2,4-diol

Chemical Property:

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Technology Process of (2R,4R)-1-(p-methoxybenzyloxy)-6-(triisopropylsilanyloxy)hexane-2,4-diol

There total 5 articles about (2R,4R)-1-(p-methoxybenzyloxy)-6-(triisopropylsilanyloxy)hexane-2,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 638222-36-3
(2R)-2-hydroxy-1-(p-methoxybenzyloxy)-6-(triisopropylsilanyloxy)hexan-4-one

: 638222-37-4
(2R,4R)-1-(p-methoxybenzyloxy)-6-(triisopropylsilanyloxy)hexane-2,4-diol

Guidance literature:: With sodium tetrahydroborate; diethyl methoxy borane; In tetrahydrofuran; methanol; at -78 ℃;
DOI:10.1021/ol035848h

Reference yield:

: 80910-01-6,108836-41-5,144069-33-0,134733-19-0
(R)-2-(((4-methoxybenzyl)oxy)methyl)oxirane

: 638222-37-4
(2R,4R)-1-(p-methoxybenzyloxy)-6-(triisopropylsilanyloxy)hexane-2,4-diol

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; heptane / 0.25 h / 20 °C

1.2: 98 percent / tetrahydrofuran; heptane / 1 h / -10 °C

2.1: 96 percent / iodine; aqueous sodium hydrogen carbonate / acetonitrile / 1 h / 0 °C

3.1: 94 percent / diethylmethoxyborane; sodium borohydride / tetrahydrofuran; methanol / -78 °C

With sodium tetrahydroborate; n-butyllithium; diethyl methoxy borane; iodine; sodium hydrogencarbonate; In tetrahydrofuran; methanol; n-heptane; acetonitrile;
DOI:10.1021/ol035848h

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 638222-37-4
(2R,4R)-1-(p-methoxybenzyloxy)-6-(triisopropylsilanyloxy)hexane-2,4-diol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 75 percent / sodium hydride; tetra-n-butylammonium iodide / tetrahydrofuran / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; heptane / 0.25 h / 20 °C

2.2: 98 percent / tetrahydrofuran; heptane / 1 h / -10 °C

3.1: 96 percent / iodine; aqueous sodium hydrogen carbonate / acetonitrile / 1 h / 0 °C

4.1: 94 percent / diethylmethoxyborane; sodium borohydride / tetrahydrofuran; methanol / -78 °C

With sodium tetrahydroborate; n-butyllithium; diethyl methoxy borane; iodine; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; methanol; n-heptane; acetonitrile;
DOI:10.1021/ol035848h