Methanesulfonic acid (2S,6S,8S)-10-benzoyl-2-methanesulfonyloxymethyl-1,4,7-trioxa-10-aza-spiro[5.5]undec-8-ylmethyl ester

Base Information

Chemical Name:Methanesulfonic acid (2S,6S,8S)-10-benzoyl-2-methanesulfonyloxymethyl-1,4,7-trioxa-10-aza-spiro[5.5]undec-8-ylmethyl ester
CAS No.:241495-70-5
Molecular Formula:C₁₈H₂₅NO₁₀S₂
Molecular Weight:479.529
Hs Code.:

Synonyms:Methanesulfonic acid (2S,6S,8S)-10-benzoyl-2-methanesulfonyloxymethyl-1,4,7-trioxa-10-aza-spiro[5.5]undec-8-ylmethyl ester

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Chemical Property of Methanesulfonic acid (2S,6S,8S)-10-benzoyl-2-methanesulfonyloxymethyl-1,4,7-trioxa-10-aza-spiro[5.5]undec-8-ylmethyl ester

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Technology Process of Methanesulfonic acid (2S,6S,8S)-10-benzoyl-2-methanesulfonyloxymethyl-1,4,7-trioxa-10-aza-spiro[5.5]undec-8-ylmethyl ester

There total 1 articles about Methanesulfonic acid (2S,6S,8S)-10-benzoyl-2-methanesulfonyloxymethyl-1,4,7-trioxa-10-aza-spiro[5.5]undec-8-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 124-63-0
methanesulfonyl chloride

: ((2R,6S,8S)-2,8-Bis-hydroxymethyl-1,4,7-trioxa-10-aza-spiro[5.5]undec-10-yl)-phenyl-methanone

: 241495-70-5
Methanesulfonic acid (2S,6S,8S)-10-benzoyl-2-methanesulfonyloxymethyl-1,4,7-trioxa-10-aza-spiro[5.5]undec-8-ylmethyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1016/S0040-4039(99)00915-6

Reference yield: 80.0%

: 241495-70-5
Methanesulfonic acid (2S,6S,8S)-10-benzoyl-2-methanesulfonyloxymethyl-1,4,7-trioxa-10-aza-spiro[5.5]undec-8-ylmethyl ester

: 241495-71-6
((2R,6S,8S)-2,8-Bis-azidomethyl-1,4,7-trioxa-10-aza-spiro[5.5]undec-10-yl)-phenyl-methanone

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 80 ℃; for 6h;
DOI:10.1016/S0040-4039(99)00915-6

Reference yield:

: 241495-70-5
Methanesulfonic acid (2S,6S,8S)-10-benzoyl-2-methanesulfonyloxymethyl-1,4,7-trioxa-10-aza-spiro[5.5]undec-8-ylmethyl ester

: 241495-72-7
((2R,6S,8R)-2,8-Bis-aminomethyl-1,4,7-trioxa-10-aza-spiro[5.5]undec-10-yl)-phenyl-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / NaN₃ / dimethylformamide / 6 h / 80 °C

2: 100 percent / H₂ / 5 percent Pd/C / 1 h / 20 °C / 2280 Torr

With sodium azide; hydrogen; palladium on activated charcoal; In N,N-dimethyl-formamide; 1: Substitution / 2: Catalytic hydrogenation;
DOI:10.1016/S0040-4039(99)00915-6