Technology Process of (2R,3R)-2-azido-5-((tert-butyldiphenylsilyl)oxy)-3-methylpentanoic acid
There total 7 articles about (2R,3R)-2-azido-5-((tert-butyldiphenylsilyl)oxy)-3-methylpentanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triflic azide; triethylamine; zinc(II) chloride;
In
methanol; dichloromethane; water;
for 5h;
Inert atmosphere;
DOI:10.1021/ol300045c
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydrogencarbonate / tetrahydrofuran; water / 12 h / 4 - 20 °C / pH 8.3 / Inert atmosphere
2.1: lithium hydroxide / tetrahydrofuran; water / 3.5 h / 4 - 20 °C / Inert atmosphere
3.1: N-ethylmorpholine; / tetrahydrofuran / -15 - 4 °C / Inert atmosphere
3.2: 4 - 20 °C / Inert atmosphere
4.1: 1H-imidazole / dichloromethane / 11 h / 20 °C / Inert atmosphere
4.2: 3.5 h / 20 °C / Inert atmosphere
5.1: triethylsilane; trifluoroacetic acid / dichloromethane / 4.25 h / 4 - 20 °C / Inert atmosphere
6.1: triflic azide; triethylamine; zinc(II) chloride / methanol; dichloromethane; water / 5 h / Inert atmosphere
With
N-ethylmorpholine;; 1H-imidazole; triethylsilane; triflic azide; sodium hydrogencarbonate; triethylamine; trifluoroacetic acid; zinc(II) chloride; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/ol300045c
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: hydrogenchloride / tetrahydrofuran; water / 0.5 h / 4 °C / Inert atmosphere
2.1: sodium hydrogencarbonate / tetrahydrofuran; water / 12 h / 4 - 20 °C / pH 8.3 / Inert atmosphere
3.1: lithium hydroxide / tetrahydrofuran; water / 3.5 h / 4 - 20 °C / Inert atmosphere
4.1: N-ethylmorpholine; / tetrahydrofuran / -15 - 4 °C / Inert atmosphere
4.2: 4 - 20 °C / Inert atmosphere
5.1: 1H-imidazole / dichloromethane / 11 h / 20 °C / Inert atmosphere
5.2: 3.5 h / 20 °C / Inert atmosphere
6.1: triethylsilane; trifluoroacetic acid / dichloromethane / 4.25 h / 4 - 20 °C / Inert atmosphere
7.1: triflic azide; triethylamine; zinc(II) chloride / methanol; dichloromethane; water / 5 h / Inert atmosphere
With
N-ethylmorpholine;; 1H-imidazole; hydrogenchloride; triethylsilane; triflic azide; sodium hydrogencarbonate; triethylamine; trifluoroacetic acid; zinc(II) chloride; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/ol300045c
