Technology Process of (2R,3R)-1-tert-butyl 5-methyl 2-(2,2-dimethyl-1-phenylpropylideneamino)-3-methylpentanedioate
There total 1 articles about (2R,3R)-1-tert-butyl 5-methyl 2-(2,2-dimethyl-1-phenylpropylideneamino)-3-methylpentanedioate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
calcium bis-iso-propoxide; [3aS-[2(3'aR*,8'aS*),3a,8a]]methylenebis[3a,8a-dihydro-8H-indeno[1,2-d]oxazole];
In
tetrahydrofuran;
at -30 ℃;
for 12h;
optical yield given as %ee;
enantioselective reaction;
Molecular sieve;
DOI:10.1021/ja8032058
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogenchloride / tetrahydrofuran; water / 0.5 h / 4 °C / Inert atmosphere
2.1: sodium hydrogencarbonate / tetrahydrofuran; water / 12 h / 4 - 20 °C / pH 8.3 / Inert atmosphere
3.1: lithium hydroxide / tetrahydrofuran; water / 3.5 h / 4 - 20 °C / Inert atmosphere
4.1: N-ethylmorpholine; / tetrahydrofuran / -15 - 4 °C / Inert atmosphere
4.2: 4 - 20 °C / Inert atmosphere
5.1: 1H-imidazole / dichloromethane / 11 h / 20 °C / Inert atmosphere
5.2: 3.5 h / 20 °C / Inert atmosphere
With
N-ethylmorpholine;; 1H-imidazole; hydrogenchloride; sodium hydrogencarbonate; lithium hydroxide;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ol300045c
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hydrogenchloride / tetrahydrofuran; water / 0.5 h / 4 °C / Inert atmosphere
2.1: sodium hydrogencarbonate / tetrahydrofuran; water / 12 h / 4 - 20 °C / pH 8.3 / Inert atmosphere
3.1: lithium hydroxide / tetrahydrofuran; water / 3.5 h / 4 - 20 °C / Inert atmosphere
4.1: N-ethylmorpholine; / tetrahydrofuran / -15 - 4 °C / Inert atmosphere
4.2: 4 - 20 °C / Inert atmosphere
5.1: 1H-imidazole / dichloromethane / 11 h / 20 °C / Inert atmosphere
5.2: 3.5 h / 20 °C / Inert atmosphere
6.1: triethylsilane; trifluoroacetic acid / dichloromethane / 4.25 h / 4 - 20 °C / Inert atmosphere
With
N-ethylmorpholine;; 1H-imidazole; hydrogenchloride; triethylsilane; sodium hydrogencarbonate; trifluoroacetic acid; lithium hydroxide;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ol300045c
