5-(Chloro-difluoro-methyl)-3-(4-chloro-3-nitro-phenyl)-isoxazole-4-carboxylic acid methyl ester

Base Information

Chemical Name:5-(Chloro-difluoro-methyl)-3-(4-chloro-3-nitro-phenyl)-isoxazole-4-carboxylic acid methyl ester
CAS No.:159693-22-8
Molecular Formula:C₁₂H₆Cl₂F₂N₂O₅
Molecular Weight:367.093
Hs Code.:

Synonyms:5-(Chloro-difluoro-methyl)-3-(4-chloro-3-nitro-phenyl)-isoxazole-4-carboxylic acid methyl ester

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Chemical Property of 5-(Chloro-difluoro-methyl)-3-(4-chloro-3-nitro-phenyl)-isoxazole-4-carboxylic acid methyl ester

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Technology Process of 5-(Chloro-difluoro-methyl)-3-(4-chloro-3-nitro-phenyl)-isoxazole-4-carboxylic acid methyl ester

There total 2 articles about 5-(Chloro-difluoro-methyl)-3-(4-chloro-3-nitro-phenyl)-isoxazole-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 143706-83-6
methyl 4,4-difluoro-4-chloro-2-butynoate

: 160192-82-5
4-chloro-3-nitro-N-hydroxy-benzimoyl chloride

: 159693-22-8
5-(Chloro-difluoro-methyl)-3-(4-chloro-3-nitro-phenyl)-isoxazole-4-carboxylic acid methyl ester

Guidance literature:: With sodium hydroxide; In dichloromethane; at -5 - 5 ℃; for 0.25h;
DOI:10.1021/jf00049a040

Reference yield:

: 66399-01-7
2-chloro-5-hydroxyiminomethylnitrobenzene

: 159693-22-8
5-(Chloro-difluoro-methyl)-3-(4-chloro-3-nitro-phenyl)-isoxazole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-chlorosuccinimide / dimethylformamide / Ambient temperature

2: 41 percent / 5percent aq. NaOH / CH₂Cl₂ / 0.25 h / -5 - 5 °C

With sodium hydroxide; N-chloro-succinimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jf00049a040

Reference yield:

: 159693-22-8
5-(Chloro-difluoro-methyl)-3-(4-chloro-3-nitro-phenyl)-isoxazole-4-carboxylic acid methyl ester

: 5-(Chloro-difluoro-methyl)-3-(4-chloro-3-nitro-phenyl)-isoxazole-4-carboxylic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1: conc. aq. HCl, CH₃COOH / 72 h / Heating

2: oxalyl chloride, DMF / CH₂Cl₂ / 1 h / Heating

3: 10percent aq. Na₂CO₃, conc. aq. NH₄OH / CH₂Cl₂ / 0.25 h

With hydrogenchloride; ammonium hydroxide; oxalyl dichloride; sodium carbonate; acetic acid; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1021/jf00049a040