p-nitrobenzyl(1R,5S,6S)-6-[(1R)-1-hydroxyethyl]-2-[(S)-5-((R)-4-hydroxymethylthiazolidin-2-yl)-1-(p-nitrobenzyloxycarbonyl)-pyrrolidin-(S)-3-ylthio]-1-methyl-1-carbapen-2-em-3-carboxylate

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Chemical Name:p-nitrobenzyl(1R,5S,6S)-6-[(1R)-1-hydroxyethyl]-2-[(S)-5-((R)-4-hydroxymethylthiazolidin-2-yl)-1-(p-nitrobenzyloxycarbonyl)-pyrrolidin-(S)-3-ylthio]-1-methyl-1-carbapen-2-em-3-carboxylate
CAS No.:466651-83-2
Molecular Formula:C₃₃H₃₇N₅O₁₁S₂
Molecular Weight:743.816
Hs Code.:

p-nitrobenzyl(1R,5S,6S)-6-[(1R)-1-hydroxyethyl]-2-[(S)-5-((R)-4-hydroxymethylthiazolidin-2-yl)-1-(p-nitrobenzyloxycarbonyl)-pyrrolidin-(S)-3-ylthio]-1-methyl-1-carbapen-2-em-3-carboxylate

Synonyms:p-nitrobenzyl(1R,5S,6S)-6-[(1R)-1-hydroxyethyl]-2-[(S)-5-((R)-4-hydroxymethylthiazolidin-2-yl)-1-(p-nitrobenzyloxycarbonyl)-pyrrolidin-(S)-3-ylthio]-1-methyl-1-carbapen-2-em-3-carboxylate

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Chemical Property of p-nitrobenzyl(1R,5S,6S)-6-[(1R)-1-hydroxyethyl]-2-[(S)-5-((R)-4-hydroxymethylthiazolidin-2-yl)-1-(p-nitrobenzyloxycarbonyl)-pyrrolidin-(S)-3-ylthio]-1-methyl-1-carbapen-2-em-3-carboxylate

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Technology Process of p-nitrobenzyl(1R,5S,6S)-6-[(1R)-1-hydroxyethyl]-2-[(S)-5-((R)-4-hydroxymethylthiazolidin-2-yl)-1-(p-nitrobenzyloxycarbonyl)-pyrrolidin-(S)-3-ylthio]-1-methyl-1-carbapen-2-em-3-carboxylate

There total 7 articles about p-nitrobenzyl(1R,5S,6S)-6-[(1R)-1-hydroxyethyl]-2-[(S)-5-((R)-4-hydroxymethylthiazolidin-2-yl)-1-(p-nitrobenzyloxycarbonyl)-pyrrolidin-(S)-3-ylthio]-1-methyl-1-carbapen-2-em-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.3%

: 93711-81-0,90776-59-3,189188-38-3
(4-nitrophenyl)methyl (4R,5R,6S)-3-[(diphenoxyphosphinyl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

: 466651-72-9
(2S,4S)-2-[((R)-4-hydroxymethyl)thiazolidin-2-yl]-4-mercapto-1-(p-nitrobenzyloxycarbonyl)pyrrolidine

: 466651-83-2
p-nitrobenzyl(1R,5S,6S)-6-[(1R)-1-hydroxyethyl]-2-[(S)-5-((R)-4-hydroxymethylthiazolidin-2-yl)-1-(p-nitrobenzyloxycarbonyl)-pyrrolidin-(S)-3-ylthio]-1-methyl-1-carbapen-2-em-3-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 ℃; for 2h;
DOI:10.1002/1521-4184(200204)335:4<152::AID-ARDP152>3.0.CO;2-B

Reference yield:

: 137049-21-9
(2S,4R)-2-formyl-4-tert-butyldimethylsilyloxy-1-(4-nitrobenzyloxycarbonyl)pyrrolidine

: 466651-83-2
p-nitrobenzyl(1R,5S,6S)-6-[(1R)-1-hydroxyethyl]-2-[(S)-5-((R)-4-hydroxymethylthiazolidin-2-yl)-1-(p-nitrobenzyloxycarbonyl)-pyrrolidin-(S)-3-ylthio]-1-methyl-1-carbapen-2-em-3-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 77.3 percent / NaHCO₃ / ethanol; H₂O / 24 h / 20 °C

2.1: 67.3 percent / NaBH₄ / ethanol / 5 h / 0 °C

3.1: 95 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

4.1: tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 20 °C

4.2: 69 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

5.1: dimethylformamide; toluene / 3 h / 70 °C

6.1: NaOH / methanol / 0.33 h

7.1: 79.3 percent / diisopropyl ethylamine / acetonitrile / 2 h / 0 °C

With sodium hydroxide; sodium tetrahydroborate; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1002/1521-4184(200204)335:4<152::AID-ARDP152>3.0.CO;2-B

Reference yield:

: (S)-2-((R)-4-Acetoxymethyl-thiazolidin-2-yl)-4-thioacetylsulfanyl-pyrrolidine-1-carboxylic acid 4-nitro-benzyl ester

: 466651-83-2
p-nitrobenzyl(1R,5S,6S)-6-[(1R)-1-hydroxyethyl]-2-[(S)-5-((R)-4-hydroxymethylthiazolidin-2-yl)-1-(p-nitrobenzyloxycarbonyl)-pyrrolidin-(S)-3-ylthio]-1-methyl-1-carbapen-2-em-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: NaOH / methanol / 0.33 h

2: 79.3 percent / diisopropyl ethylamine / acetonitrile / 2 h / 0 °C

With sodium hydroxide; N-ethyl-N,N-diisopropylamine; In methanol; acetonitrile;
DOI:10.1002/1521-4184(200204)335:4<152::AID-ARDP152>3.0.CO;2-B