(2S,4R)-2-formyl-4-tert-butyldimethylsilyloxy-1-(4-nitrobenzyloxycarbonyl)pyrrolidine

Base Information

Chemical Name:(2S,4R)-2-formyl-4-tert-butyldimethylsilyloxy-1-(4-nitrobenzyloxycarbonyl)pyrrolidine
CAS No.:137049-21-9
Molecular Formula:C₁₉H₂₈N₂O₆Si
Molecular Weight:408.527
Hs Code.:

Synonyms:(2S,4R)-2-formyl-4-tert-butyldimethylsilyloxy-1-(4-nitrobenzyloxycarbonyl)pyrrolidine

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Chemical Property of (2S,4R)-2-formyl-4-tert-butyldimethylsilyloxy-1-(4-nitrobenzyloxycarbonyl)pyrrolidine

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Technology Process of (2S,4R)-2-formyl-4-tert-butyldimethylsilyloxy-1-(4-nitrobenzyloxycarbonyl)pyrrolidine

There total 5 articles about (2S,4R)-2-formyl-4-tert-butyldimethylsilyloxy-1-(4-nitrobenzyloxycarbonyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 104795-10-0
(2S,4R)-4-tert-butyldimethylsiloxy-2-hydroxymethyl-N-(4-nitrobenzyloxycarbonyl) pyrrolidine

: 137049-21-9
(2S,4R)-2-formyl-4-tert-butyldimethylsilyloxy-1-(4-nitrobenzyloxycarbonyl)pyrrolidine

Guidance literature:: With sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine; at 0 - 20 ℃; for 0.5h;
DOI:10.1016/S0960-894X(99)00646-0

Reference yield:

: 101803-29-6
(2S,4R)-4-hydroxy-2-methoxycarbonyl-1-(4-nitrobenzyloxycarbonyl)pyrrolidine

: 137049-21-9
(2S,4R)-2-formyl-4-tert-butyldimethylsilyloxy-1-(4-nitrobenzyloxycarbonyl)pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / imidazole / dimethylformamide / 1.5 h / 0 - 20 °C

2: 95 percent / NaBH₄; LiCl / tetrahydrofuran; ethanol / 4 h / 0 - 20 °C

3: 84 percent / pyridine sulfur trioxide complex; Et₃N; DMSO / 0.5 h / 0 - 20 °C

With 1H-imidazole; sodium tetrahydroborate; sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine; lithium chloride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; 1: silylation / 2: Reduction / 3: Oxidation;
DOI:10.1016/S0960-894X(99)00646-0

Reference yield:

: 117811-69-5
(2S,4R)-4-t-butyldimethylsilyloxy-2-methoxycarbonyl-1-(4-nitrobenzyloxycarbonyl)pyrrolidine

: 137049-21-9
(2S,4R)-2-formyl-4-tert-butyldimethylsilyloxy-1-(4-nitrobenzyloxycarbonyl)pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / NaBH₄; LiCl / tetrahydrofuran; ethanol / 4 h / 0 - 20 °C

2: 84 percent / pyridine sulfur trioxide complex; Et₃N; DMSO / 0.5 h / 0 - 20 °C

With sodium tetrahydroborate; sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine; lithium chloride; In tetrahydrofuran; ethanol; 1: Reduction / 2: Oxidation;
DOI:10.1016/S0960-894X(99)00646-0