(S)-4-Benzyl-3-((S)-2-{6-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridin-3-ylmethyl}-tetrahydro-furan-2-carbonyl)-oxazolidin-2-one

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Chemical Name:(S)-4-Benzyl-3-((S)-2-{6-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridin-3-ylmethyl}-tetrahydro-furan-2-carbonyl)-oxazolidin-2-one
CAS No.:919361-22-1
Molecular Formula:C₃₃H₃₃N₃O₆
Molecular Weight:567.642
Hs Code.:

Synonyms:(S)-4-Benzyl-3-((S)-2-{6-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridin-3-ylmethyl}-tetrahydro-furan-2-carbonyl)-oxazolidin-2-one

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Chemical Property of (S)-4-Benzyl-3-((S)-2-{6-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridin-3-ylmethyl}-tetrahydro-furan-2-carbonyl)-oxazolidin-2-one

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Technology Process of (S)-4-Benzyl-3-((S)-2-{6-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridin-3-ylmethyl}-tetrahydro-furan-2-carbonyl)-oxazolidin-2-one

There total 11 articles about (S)-4-Benzyl-3-((S)-2-{6-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridin-3-ylmethyl}-tetrahydro-furan-2-carbonyl)-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 784149-88-8
(4S)-4-benzyl-3-(tetrahydrofuran-2-ylcarbonyl)-1,3-oxazolidin-2-one

: 919361-00-5
2-methyl-3-{6-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridin-3-yl}-propionic acid

: 919361-22-1
(S)-4-Benzyl-3-((S)-2-{6-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridin-3-ylmethyl}-tetrahydro-furan-2-carbonyl)-oxazolidin-2-one

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at -50 ℃; for 2h;
DOI:10.1016/j.bmcl.2006.08.110

Reference yield:

: 157169-61-4
5-formyl-2-[2-(5-methyl-2-phenyl-4-oxazolyl)-ethoxy]pyridine

: 919361-22-1
(S)-4-Benzyl-3-((S)-2-{6-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridin-3-ylmethyl}-tetrahydro-furan-2-carbonyl)-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / NaBH₄ / methanol / 1 h / 20 °C

2: 100 percent / (COCl)2 / dimethylformamide; CH₂Cl₂ / 3 h / 20 °C

3: 75 percent / NaI / acetone / 4 h / 20 °C

4: NaHMDS / tetrahydrofuran / 3 h / -50 °C

5: LiOH / tetrahydrofuran; methanol; H₂O / 16 h / 20 °C

6: 85 percent / NaHMDS / tetrahydrofuran / 2 h / -50 °C

With lithium hydroxide; sodium tetrahydroborate; oxalyl dichloride; sodium hexamethyldisilazane; sodium iodide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; 3: Finkelstein reaction;
DOI:10.1016/j.bmcl.2006.08.110

Reference yield:

: 784149-29-7
5-bromo-2-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridine

: 919361-22-1
(S)-4-Benzyl-3-((S)-2-{6-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridin-3-ylmethyl}-tetrahydro-furan-2-carbonyl)-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: nBuLi / diethyl ether; tetrahydrofuran / -78 °C

1.2: 72 percent / diethyl ether; tetrahydrofuran / 1 h / 0 °C

2.1: 100 percent / NaBH₄ / methanol / 1 h / 20 °C

3.1: 100 percent / (COCl)2 / dimethylformamide; CH₂Cl₂ / 3 h / 20 °C

4.1: 75 percent / NaI / acetone / 4 h / 20 °C

5.1: NaHMDS / tetrahydrofuran / 3 h / -50 °C

6.1: LiOH / tetrahydrofuran; methanol; H₂O / 16 h / 20 °C

7.1: 85 percent / NaHMDS / tetrahydrofuran / 2 h / -50 °C

With lithium hydroxide; sodium tetrahydroborate; n-butyllithium; oxalyl dichloride; sodium hexamethyldisilazane; sodium iodide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetone; 4.1: Finkelstein reaction;
DOI:10.1016/j.bmcl.2006.08.110