(S)-2-{4-[(R)-4-(4-fluoro-phenyl)-4,5-dihydro-oxazol-2-yl]phenyl}morpholine

Base Information

Chemical Name:(S)-2-{4-[(R)-4-(4-fluoro-phenyl)-4,5-dihydro-oxazol-2-yl]phenyl}morpholine
CAS No.:1447830-37-6
Molecular Formula:C₁₉H₁₉FN₂O₂
Molecular Weight:326.37
Hs Code.:

Synonyms:(S)-2-{4-[(R)-4-(4-fluoro-phenyl)-4,5-dihydro-oxazol-2-yl]phenyl}morpholine

Suppliers and Price of (S)-2-{4-[(R)-4-(4-fluoro-phenyl)-4,5-dihydro-oxazol-2-yl]phenyl}morpholine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-{4-[(R)-4-(4-fluoro-phenyl)-4,5-dihydro-oxazol-2-yl]phenyl}morpholine

Chemical Property:

Purity/Quality:

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Technology Process of (S)-2-{4-[(R)-4-(4-fluoro-phenyl)-4,5-dihydro-oxazol-2-yl]phenyl}morpholine

There total 4 articles about (S)-2-{4-[(R)-4-(4-fluoro-phenyl)-4,5-dihydro-oxazol-2-yl]phenyl}morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-((R)-1-(4-fluorophenyl)-2-hydroxyethyl)-4-((S)-morpholin-2-yl)benzamide

: 1447830-37-6
(S)-2-{4-[(R)-4-(4-fluoro-phenyl)-4,5-dihydro-oxazol-2-yl]phenyl}morpholine

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at 20 ℃; for 5h;

Reference yield:

: 1131220-40-0
(S)-4-(4-(tert-butoxycarbonyl)morpholin-2-yl)benzoic acid

: 1447830-37-6
(S)-2-{4-[(R)-4-(4-fluoro-phenyl)-4,5-dihydro-oxazol-2-yl]phenyl}morpholine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 °C

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3: diethylamino-sulfur trifluoride / dichloromethane / 5 h / 20 °C

With dmap; diethylamino-sulfur trifluoride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 1447831-83-5
(S)-tert-butyl 2-(4-((R)-1-(4-fluorophenyl)-2-hydroxyethylcarbamoyl)phenyl)morpholine-4-carboxylate

: 1447830-37-6
(S)-2-{4-[(R)-4-(4-fluoro-phenyl)-4,5-dihydro-oxazol-2-yl]phenyl}morpholine

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2: diethylamino-sulfur trifluoride / dichloromethane / 5 h / 20 °C

With diethylamino-sulfur trifluoride; trifluoroacetic acid; In dichloromethane;