(S)-tert-butyl 2-(4-((R)-1-(4-fluorophenyl)-2-hydroxyethylcarbamoyl)phenyl)morpholine-4-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 2-(4-((R)-1-(4-fluorophenyl)-2-hydroxyethylcarbamoyl)phenyl)morpholine-4-carboxylate
CAS No.:1447831-83-5
Molecular Formula:C₂₄H₂₉FN₂O₅
Molecular Weight:444.503
Hs Code.:

Synonyms:(S)-tert-butyl 2-(4-((R)-1-(4-fluorophenyl)-2-hydroxyethylcarbamoyl)phenyl)morpholine-4-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-tert-butyl 2-(4-((R)-1-(4-fluorophenyl)-2-hydroxyethylcarbamoyl)phenyl)morpholine-4-carboxylate

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Technology Process of (S)-tert-butyl 2-(4-((R)-1-(4-fluorophenyl)-2-hydroxyethylcarbamoyl)phenyl)morpholine-4-carboxylate

There total 1 articles about (S)-tert-butyl 2-(4-((R)-1-(4-fluorophenyl)-2-hydroxyethylcarbamoyl)phenyl)morpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1131220-40-0
(S)-4-(4-(tert-butoxycarbonyl)morpholin-2-yl)benzoic acid

: 174770-74-2
(R)-2-amino-2-(4-fluorophenyl)ethanol

: 1447831-83-5
(S)-tert-butyl 2-(4-((R)-1-(4-fluorophenyl)-2-hydroxyethylcarbamoyl)phenyl)morpholine-4-carboxylate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 1447831-83-5
(S)-tert-butyl 2-(4-((R)-1-(4-fluorophenyl)-2-hydroxyethylcarbamoyl)phenyl)morpholine-4-carboxylate

: N-((R)-1-(4-fluorophenyl)-2-hydroxyethyl)-4-((S)-morpholin-2-yl)benzamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1447831-83-5
(S)-tert-butyl 2-(4-((R)-1-(4-fluorophenyl)-2-hydroxyethylcarbamoyl)phenyl)morpholine-4-carboxylate

: 1447830-37-6
(S)-2-{4-[(R)-4-(4-fluoro-phenyl)-4,5-dihydro-oxazol-2-yl]phenyl}morpholine

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2: diethylamino-sulfur trifluoride / dichloromethane / 5 h / 20 °C

With diethylamino-sulfur trifluoride; trifluoroacetic acid; In dichloromethane;