(+)-methyl 2-carbomethoxy-4-nitro-3-(4-methylphenyl)-butyrate

Base Information

Chemical Name:(+)-methyl 2-carbomethoxy-4-nitro-3-(4-methylphenyl)-butyrate
CAS No.:945990-49-8
Molecular Formula:C₁₄H₁₇NO₆
Molecular Weight:295.292
Hs Code.:

Synonyms:(+)-methyl 2-carbomethoxy-4-nitro-3-(4-methylphenyl)-butyrate

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Chemical Property of (+)-methyl 2-carbomethoxy-4-nitro-3-(4-methylphenyl)-butyrate

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Technology Process of (+)-methyl 2-carbomethoxy-4-nitro-3-(4-methylphenyl)-butyrate

There total 5 articles about (+)-methyl 2-carbomethoxy-4-nitro-3-(4-methylphenyl)-butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 101671-00-5,5153-68-4
(E)-2-(4-methylphenyl)-1-nitroethene

: 108-59-8
malonic acid dimethyl ester

: 945990-49-8
(+)-methyl 2-carbomethoxy-4-nitro-3-(4-methylphenyl)-butyrate

Guidance literature:: With (5,7-bis(trifluoromethyl)-1H-benzoimidazol-2-yl)-9-epiquinidine amine; In dichloromethane; at -20 ℃; for 40h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1002/adsc.200900787

Reference yield:

: 101671-00-5,5153-68-4
(E)-2-(4-methylphenyl)-1-nitroethene

: 108-59-8
malonic acid dimethyl ester

: (-)-methyl 2-carbomethoxy-4-nitro-3-(4-methylphenyl)-butyrate

: 945990-49-8
(+)-methyl 2-carbomethoxy-4-nitro-3-(4-methylphenyl)-butyrate

Guidance literature:: With 9-amino-(9-deoxy)epi-cinchonidine; In dichloromethane; at -20 ℃; for 48h; Title compound not separated from byproducts;
DOI:10.1039/b508833j

Reference yield:

: 7559-36-6,5153-68-4
4-methyl-β-nitrostyrene

: 108-59-8
malonic acid dimethyl ester

: (-)-methyl 2-carbomethoxy-4-nitro-3-(4-methylphenyl)-butyrate

: 945990-49-8
(+)-methyl 2-carbomethoxy-4-nitro-3-(4-methylphenyl)-butyrate

Guidance literature:: With C₄₆H₅₇N₃O₈; triethylamine; In toluene; at -78 ℃; for 72h; Overall yield = 65 %; Overall yield = 38 mg; enantioselective reaction;
DOI:10.1021/acs.orglett.9b01170