m-Chlorophenylethylamine hydrochloride

Base Information

• Chemical Name: m-Chlorophenylethylamine hydrochloride
• CAS No.: 89042-13-7
• Molecular Formula: C₈H₁₀ClN*ClH
• Molecular Weight: 192.088
• Mol file: 89042-13-7.mol

Synonyms:m-Chlorophenylethylamine hydrochloride

Chemical Property of m-Chlorophenylethylamine hydrochloride

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of m-Chlorophenylethylamine hydrochloride

There total 4 articles about m-Chlorophenylethylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-chlorophenethyl azide (1316652-69-3) → m-Chlorophenylethylamine hydrochloride (89042-13-7)

Guidance literature:

3-chlorophenethyl azide; With triphenylphosphine; at 110 ℃; for 20h; Green chemistry;

With hydrogenchloride; In 1,4-dioxane; diethyl ether; Green chemistry;

DOI:10.1039/c8gc02136h

Reference yield: 45.0%

→ m-Chlorophenylethylamine hydrochloride (89042-13-7)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In ethanol; at 0 ℃; for 6h; Inert atmosphere;

Reference yield:

2-(3-chlorophenyl)ethanol (5182-44-5) → m-Chlorophenylethylamine hydrochloride (89042-13-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 5.5 h / -30 - 20 °C / Inert atmosphere

2.1: sodium azide / N,N-dimethyl-formamide / 20 h / 23 °C

3.1: triphenylphosphine / 20 h / 110 °C / Green chemistry

3.2: Green chemistry

With sodium azide; triethylamine; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; 3.1: |Staudinger Azide Reduction;

DOI:10.1039/c8gc02136h

upstream raw materials:

3-chlorophenethyl azide

2-(3-chlorophenyl)ethanol

Downstream raw materials:

Methyl-6-<(2-endo,3-exo)-3-<<2-(3-chlorphenyl)ethyl>carbamoyl>bicyclo<2.2.1>hept-2-yl>hexanoat