6-Fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1-(4-trifluoromethyl-benzyl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Base Information

Chemical Name:6-Fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1-(4-trifluoromethyl-benzyl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester
CAS No.:214602-58-1
Molecular Formula:C₂₅H₂₅F₄N₃O₃
Molecular Weight:491.485
Hs Code.:

Synonyms:6-Fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1-(4-trifluoromethyl-benzyl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Suppliers and Price of 6-Fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1-(4-trifluoromethyl-benzyl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-Fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1-(4-trifluoromethyl-benzyl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-Fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1-(4-trifluoromethyl-benzyl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

There total 3 articles about 6-Fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1-(4-trifluoromethyl-benzyl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 109-01-3
1-methyl-piperazine

: 214602-23-0
ethyl 6,7-difluoro-4-oxo-1-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxylate

: 214602-58-1
6-Fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1-(4-trifluoromethyl-benzyl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Guidance literature:: With pyridine; at 70 - 80 ℃; for 16h;
DOI:10.1002/jhet.5570350429

Reference yield:

: 121873-01-6
6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester

: 214602-58-1
6-Fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1-(4-trifluoromethyl-benzyl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / K₂CO₃ / dimethylformamide / 12 h / 90 - 100 °C

2: 96 percent / pyridine / 16 h / 70 - 80 °C

With pyridine; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570350429

Reference yield:

: 939-99-1
4-trifluoromethylbenzyl chloride

: 214602-58-1
6-Fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1-(4-trifluoromethyl-benzyl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / K₂CO₃ / dimethylformamide / 12 h / 90 - 100 °C

2: 96 percent / pyridine / 16 h / 70 - 80 °C

With pyridine; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570350429