1-(4-methoxyphenyl)-N'-[(E)-(4-nitrophenyl)methylidene]-5-oxopyrrolidine-3-carbohydrazide

Base Information

Chemical Name:1-(4-methoxyphenyl)-N'-[(E)-(4-nitrophenyl)methylidene]-5-oxopyrrolidine-3-carbohydrazide
CAS No.:6063-69-0
Molecular Formula:C19H18N4O5
Molecular Weight:188.08
Hs Code.:
DSSTox Substance ID:DTXSID50417422
ChEMBL ID:CHEMBL3191130

Synonyms:1-(4-methoxyphenyl)-N'-[(E)-(4-nitrophenyl)methylidene]-5-oxopyrrolidine-3-carbohydrazide;6063-69-0;STK013665;1-(4-methoxyphenyl)-N-[(E)-(4-nitrophenyl)methylideneamino]-5-oxopyrrolidine-3-carboxamide;MLS000684282;CHEMBL3191130;DTXSID50417422;AKOS000340576;AKOS022083585;SMR000268098;BIM-0043418.P001;SR-01000226598;SR-01000226598-1;1-(4-methoxyphenyl)-N'-(4-nitrobenzylidene)-5-oxo-3-pyrrolidinecarbohydrazide

Suppliers and Price of 1-(4-methoxyphenyl)-N'-[(E)-(4-nitrophenyl)methylidene]-5-oxopyrrolidine-3-carbohydrazide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-methoxyphenyl)-N'-[(E)-(4-nitrophenyl)methylidene]-5-oxopyrrolidine-3-carbohydrazide

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:382.12771969
Heavy Atom Count:28
Complexity:604

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)N2CC(CC2=O)C(=O)NN=CC3=CC=C(C=C3)[N+](=O)[O-]
Isomeric SMILES:COC1=CC=C(C=C1)N2CC(CC2=O)C(=O)N/N=C/C3=CC=C(C=C3)[N+](=O)[O-]

Technology Process of 1-(4-methoxyphenyl)-N'-[(E)-(4-nitrophenyl)methylidene]-5-oxopyrrolidine-3-carbohydrazide

There total 8 articles about 1-(4-methoxyphenyl)-N'-[(E)-(4-nitrophenyl)methylidene]-5-oxopyrrolidine-3-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 873-51-8
phenylborondichloride

: 121-44-8
triethylamine

: 111-33-1
1,3-bis(methylamino)propane

: 554-68-7
triethylamine hydrochloride

: 6063-69-0
1,3-dimethyl-2-phenyl-[1,3,2]diazaborinane

Guidance literature:: DOI:10.1021/ic50091a037

Reference yield:

: 6063-74-7
1-methyl-2-phenyl-[1,3,2]diazaborinane

: 77-78-1
dimethyl sulfate

: 1321604-69-6
C₁₂H₁₉BN₂

: 6063-69-0
1,3-dimethyl-2-phenyl-[1,3,2]diazaborinane

Guidance literature:: 1-methyl-2-phenyl-[1,3,2]diazaborinane; With bis(2,2,6,6-tetramethylpiperidyl)magnesium-bis(lithium chloride); In tetrahydrofuran; hexane; at 0 ℃; for 2.53333h; Reflux; Inert atmosphere;

dimethyl sulfate; In tetrahydrofuran; hexane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1002/chem.201101022

Reference yield:

: 98-80-6
phenylboronic acid

: 6063-69-0
1,3-dimethyl-2-phenyl-[1,3,2]diazaborinane

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene / Inert atmosphere; Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / Cooling; Inert atmosphere

2.2: 20 °C / Cooling; Inert atmosphere

With n-butyllithium; In tetrahydrofuran; hexane; toluene;
DOI:10.1002/chem.201101022