Technology Process of 5-(2-methoxyphenyl)-2-methyl-2-azabicyclo[3.3.1]nonane
There total 4 articles about 5-(2-methoxyphenyl)-2-methyl-2-azabicyclo[3.3.1]nonane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen; acetic acid;
palladium on activated charcoal;
In
methanol;
at 60 ℃;
for 2h;
DOI:10.1016/j.bmc.2004.05.038
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: n-BuLi / hexane; tetrahydrofuran / -70 - 1 °C
1.2: 23.1 percent / tetrahydrofuran / 20 °C
2.1: 15.6 percent / p-toluenesulfonic acid monohydrate / toluene / 18 h / Heating
3.1: sec-BuLi / cyclohexane; tetrahydrofuran / 1 h / -50 - -20 °C
3.2: tetrahydrofuran / 2 h / -50 - 0 °C
4.1: HCO2H; H3PO4 / 88 h / 20 °C
5.1: 413 mg / NaBH4 / methanol / 1.5 h / 20 °C
6.1: 85 percent / AcOH; H2 / Pd/C / methanol / 2 h / 60 °C
With
sodium tetrahydroborate; n-butyllithium; formic acid; phosphoric acid; hydrogen; sec.-butyllithium; toluene-4-sulfonic acid; acetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; hexane; cyclohexane; toluene;
DOI:10.1016/j.bmc.2004.05.038
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sec-BuLi / cyclohexane; tetrahydrofuran / 1 h / -50 - -20 °C
1.2: tetrahydrofuran / 2 h / -50 - 0 °C
2.1: HCO2H; H3PO4 / 88 h / 20 °C
3.1: 413 mg / NaBH4 / methanol / 1.5 h / 20 °C
4.1: 85 percent / AcOH; H2 / Pd/C / methanol / 2 h / 60 °C
With
sodium tetrahydroborate; formic acid; phosphoric acid; hydrogen; sec.-butyllithium; acetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; cyclohexane;
DOI:10.1016/j.bmc.2004.05.038
