(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)-methylsulfonamido)benzoyloxy)acetoxy)ethyl)pyridine 1-oxide hydrochloride

Base Information

Chemical Name:(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)-methylsulfonamido)benzoyloxy)acetoxy)ethyl)pyridine 1-oxide hydrochloride
CAS No.:1428847-56-6
Molecular Formula:C₃₅H₃₉Cl₂F₂N₃O₁₁S*ClH
Molecular Weight:855.138
Hs Code.:

(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)-methylsulfonamido)benzoyloxy)acetoxy)ethyl)pyridine 1-oxide hydrochloride

Synonyms:(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)-methylsulfonamido)benzoyloxy)acetoxy)ethyl)pyridine 1-oxide hydrochloride

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Chemical Property of (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)-methylsulfonamido)benzoyloxy)acetoxy)ethyl)pyridine 1-oxide hydrochloride

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Technology Process of (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)-methylsulfonamido)benzoyloxy)acetoxy)ethyl)pyridine 1-oxide hydrochloride

There total 8 articles about (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)-methylsulfonamido)benzoyloxy)acetoxy)ethyl)pyridine 1-oxide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428847-50-0
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)-phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)-benzoyloxy)acetoxy)ethyl)pyridine 1-oxide

: 1428847-56-6
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)-methylsulfonamido)benzoyloxy)acetoxy)ethyl)pyridine 1-oxide hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; ethyl acetate;

Reference yield:

: (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-hydroxyethyl)pyridine 1-oxide

: 1428847-56-6
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)-methylsulfonamido)benzoyloxy)acetoxy)ethyl)pyridine 1-oxide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C

2: dichloromethane / 120 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 8 h / 40 °C

4: hydrogenchloride / diethyl ether; ethyl acetate

With hydrogenchloride; dmap; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 24812-90-6
methyl 3-amino-4-methoxybenzoate

: 1428847-56-6
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)-methylsulfonamido)benzoyloxy)acetoxy)ethyl)pyridine 1-oxide hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1: pyridine / 2 h / 20 °C

2: dmap / dichloromethane / 2 h / 20 °C

3: tin(II) chloride dihdyrate; lithium hydroxide / tetrahydrofuran / 24 h / 20 °C

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

5: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 3 h / 1034.32 Torr

6: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C

7: dichloromethane / 120 h / 20 °C

8: potassium carbonate / N,N-dimethyl-formamide / 8 h / 40 °C

9: hydrogenchloride / diethyl ether; ethyl acetate

With pyridine; hydrogenchloride; dmap; tin(II) chloride dihdyrate; palladium 10% on activated carbon; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;