(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)-phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)-benzoyloxy)acetoxy)ethyl)pyridine 1-oxide

Base Information

Chemical Name:(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)-phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)-benzoyloxy)acetoxy)ethyl)pyridine 1-oxide
CAS No.:1428847-50-0
Molecular Formula:C₃₅H₃₉Cl₂F₂N₃O₁₁S
Molecular Weight:818.677
Hs Code.:

(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)-phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)-benzoyloxy)acetoxy)ethyl)pyridine 1-oxide

Synonyms:(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)-phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)-benzoyloxy)acetoxy)ethyl)pyridine 1-oxide

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Chemical Property of (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)-phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)-benzoyloxy)acetoxy)ethyl)pyridine 1-oxide

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Technology Process of (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)-phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)-benzoyloxy)acetoxy)ethyl)pyridine 1-oxide

There total 8 articles about (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)-phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)-benzoyloxy)acetoxy)ethyl)pyridine 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 3240-94-6
N-(2-chlorethyl)morpholine

: 1428847-49-7
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(4-methoxy-3-(methylsulfonamido)benzoyloxy)-acetoxy)ethyl)pyridine 1-oxide

: 1428847-50-0
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)-phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)-benzoyloxy)acetoxy)ethyl)pyridine 1-oxide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 8h;

Reference yield:

: (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-hydroxyethyl)pyridine 1-oxide

: 1428847-50-0
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)-phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)-benzoyloxy)acetoxy)ethyl)pyridine 1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C

2: dichloromethane / 120 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 8 h / 40 °C

With dmap; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 24812-90-6
methyl 3-amino-4-methoxybenzoate

: 1428847-50-0
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)-phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)-benzoyloxy)acetoxy)ethyl)pyridine 1-oxide

Guidance literature:: Multi-step reaction with 8 steps

1: pyridine / 2 h / 20 °C

2: dmap / dichloromethane / 2 h / 20 °C

3: tin(II) chloride dihdyrate; lithium hydroxide / tetrahydrofuran / 24 h / 20 °C

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

5: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 3 h / 1034.32 Torr

6: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C

7: dichloromethane / 120 h / 20 °C

8: potassium carbonate / N,N-dimethyl-formamide / 8 h / 40 °C

With pyridine; dmap; tin(II) chloride dihdyrate; palladium 10% on activated carbon; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;