2-{[(3,4-difluorophenyl)methyl]oxy}-5-[(Z)-(hydroxyimino)methyl]-N-3-pyridinylbenzamide

Base Information

Chemical Name:2-{[(3,4-difluorophenyl)methyl]oxy}-5-[(Z)-(hydroxyimino)methyl]-N-3-pyridinylbenzamide
CAS No.:1285514-85-3
Molecular Formula:C₂₀H₁₅F₂N₃O₃
Molecular Weight:383.354
Hs Code.:

Synonyms:2-{[(3,4-difluorophenyl)methyl]oxy}-5-[(Z)-(hydroxyimino)methyl]-N-3-pyridinylbenzamide

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Chemical Property of 2-{[(3,4-difluorophenyl)methyl]oxy}-5-[(Z)-(hydroxyimino)methyl]-N-3-pyridinylbenzamide

Chemical Property:

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Technology Process of 2-{[(3,4-difluorophenyl)methyl]oxy}-5-[(Z)-(hydroxyimino)methyl]-N-3-pyridinylbenzamide

There total 5 articles about 2-{[(3,4-difluorophenyl)methyl]oxy}-5-[(Z)-(hydroxyimino)methyl]-N-3-pyridinylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1285514-75-1
2-{[(3,4-difluorophenyl)methyl]oxy}-5-formyl-N-3-pyridinylbenzamide

: 1285514-85-3
2-{[(3,4-difluorophenyl)methyl]oxy}-5-[(Z)-(hydroxyimino)methyl]-N-3-pyridinylbenzamide

Guidance literature:: With pyridine; hydroxylamine hydrochloride; In methanol; at 20 ℃; for 0.5h;

Reference yield:

: 462-08-8
pyridin-3-ylamine

: 1285514-85-3
2-{[(3,4-difluorophenyl)methyl]oxy}-5-[(Z)-(hydroxyimino)methyl]-N-3-pyridinylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethylmorpholine; / N,N-dimethyl-formamide / 20 °C

2: hydroxylamine hydrochloride; pyridine / methanol / 0.5 h / 20 °C

With N-ethylmorpholine;; pyridine; hydroxylamine hydrochloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 616-76-2
2-hydroxy-5-formylbenzoic acid

: 1285514-85-3
2-{[(3,4-difluorophenyl)methyl]oxy}-5-[(Z)-(hydroxyimino)methyl]-N-3-pyridinylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

2.2: pH 1

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethylmorpholine; / N,N-dimethyl-formamide / 20 °C

4.1: hydroxylamine hydrochloride; pyridine / methanol / 0.5 h / 20 °C

With N-ethylmorpholine;; pyridine; hydroxylamine hydrochloride; water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;