6-[2-(3-hydroxypropyl)[1,3]dithian-2-ylmethyl]-2,4-dimethoxy-3-methylbenzaldehyde

Base Information

Chemical Name:6-[2-(3-hydroxypropyl)[1,3]dithian-2-ylmethyl]-2,4-dimethoxy-3-methylbenzaldehyde
CAS No.:853247-15-1
Molecular Formula:C₁₈H₂₆O₄S₂
Molecular Weight:370.534
Hs Code.:

Synonyms:6-[2-(3-hydroxypropyl)[1,3]dithian-2-ylmethyl]-2,4-dimethoxy-3-methylbenzaldehyde

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Chemical Property of 6-[2-(3-hydroxypropyl)[1,3]dithian-2-ylmethyl]-2,4-dimethoxy-3-methylbenzaldehyde

Chemical Property:

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Technology Process of 6-[2-(3-hydroxypropyl)[1,3]dithian-2-ylmethyl]-2,4-dimethoxy-3-methylbenzaldehyde

There total 5 articles about 6-[2-(3-hydroxypropyl)[1,3]dithian-2-ylmethyl]-2,4-dimethoxy-3-methylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 606926-19-6
tert-butyl-{3-[2-(2-dimethoxymethyl-3,5-dimethoxy-4-methylbenzyl)-[1,3]dithian-2-yl]propoxy}dimethylsilane

: 853247-15-1
6-[2-(3-hydroxypropyl)[1,3]dithian-2-ylmethyl]-2,4-dimethoxy-3-methylbenzaldehyde

Guidance literature:: With hydrogenchloride; In acetone; at 20 ℃; for 4h;
DOI:10.1021/jo050414g

Reference yield:

: 705-76-0
3,5-dimethoxybenzyl alcohol

: 853247-15-1
6-[2-(3-hydroxypropyl)[1,3]dithian-2-ylmethyl]-2,4-dimethoxy-3-methylbenzaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: 87 percent / POCl₃ / 60 °C

2.1: 95 percent / p-TsOH; molecular sieves 4 Angstroem / methanol / 50 °C

3.1: n-BuLi / tetrahydrofuran / -78 - -20 °C

3.2: 42 percent / tetrahydrofuran

4.1: 75 percent / n-BuLi / tetrahydrofuran / -78 - -10 °C

5.1: 92 percent / HCl / acetone / 4 h / 20 °C

With hydrogenchloride; n-butyllithium; 4 A molecular sieve; toluene-4-sulfonic acid; trichlorophosphate; In tetrahydrofuran; methanol; acetone;
DOI:10.1021/jo050414g

Reference yield:

: 166322-67-4
2-(chloromethyl)-4,6-dimethoxy-benzaldehyde

: 853247-15-1
6-[2-(3-hydroxypropyl)[1,3]dithian-2-ylmethyl]-2,4-dimethoxy-3-methylbenzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / p-TsOH; molecular sieves 4 Angstroem / methanol / 50 °C

2.1: n-BuLi / tetrahydrofuran / -78 - -20 °C

2.2: 42 percent / tetrahydrofuran

3.1: 75 percent / n-BuLi / tetrahydrofuran / -78 - -10 °C

4.1: 92 percent / HCl / acetone / 4 h / 20 °C

With hydrogenchloride; n-butyllithium; 4 A molecular sieve; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; acetone;
DOI:10.1021/jo050414g