166322-67-4Relevant academic research and scientific papers
Studies toward the synthesis of caramboxin analogues
Oliveira Filho, Ronaldo E.,Higa, Vanessa M.,Omori, álvaro T.
, p. 528 - 540 (2019/08/26)
Intrigued by the recent discovery of caramboxin by Brazilian researchers, we present the results from our studies toward the racemic synthesis of caramboxin analogs through the ortho-carboxylation of 3,5-dimethoxy benzyl derivatives. Three different approaches were tested, and the route involving a Vilsmeier-Haack formylation followed by a Lindgren oxidation provide a potential intermediate for the synthesis of several caramboxin analogs.
Total Synthesis of Tetarimycin A, (±)-Naphthacemycin A9, and (±)-Fasamycin A: Structure-Activity Relationship Studies against Drug-Resistant Bacteria
Huang, Jing-Kai,Yang Lauderdale, Tsai-Ling,Lin, Chun-Cheng,Shia, Kak-Shan
, p. 6508 - 6523 (2018/05/30)
Making use of a reductive olefin coupling reaction and Michael-Dieckmann condensation as two key operations, we have completed a concise total synthesis of tetarimycin A, (±)-naphthacemycin A9, and (±)-fasamycin A in a highly convergent and pra
Synthesis studies toward chloroazaphilone and vinylogous γ-pyridones: Two common natural product core structures
Wei, Wan-Guo,Yao, Zhu-Jun
, p. 4585 - 4590 (2007/10/03)
Chloroazaphilone is a common structure found in a number of natural products. Reported herein is a practical synthesis of a model chloroazaphilone that utilizes Pb(OAc)4 oxidation of HClO4/ HOAc pyrinium salt in a key one-pot operati
Novel macrocycles and uses thereof
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, (2008/06/13)
The present invention relates to compounds having the structure (I) (and pharmaceutically acceptable derivatives thereof) wherein R1-R4, Z, X, A-B, D-E, G-J, and K-L are as defined herein, the synthesis thereof and the use of these c
Concise asymmetric syntheses of radicicol and monocillin I
Garbaccio,Stachel,Baeschlin,Danishefsky
, p. 10903 - 10908 (2007/10/03)
Radicicol (1) exhibits potent anticancer properties in vitro, which are likely to be mediated through its high affinity (20 nM) for the molecular chaperone Hsp90. Recently, we reported the results of a synthetic program targeting radicicol (1) and monocil
Efficient asymmetric synthesis of radicicol dimethyl ether: a novel application of ring-forming olefin metathesis.
Garbaccio,Danishefsky
, p. 3127 - 3129 (2007/10/03)
A concise, stereospecific synthesis of radicicol dimethyl ether is presented. The strategy relies on a convergent three-stage assembly of the 14-membered lactone which has, as a key transformation, a novel ring-forming metathesis reaction utilizing a viny
