Technology Process of methyl (15S)-16-(4-nitrobenzoyloxy)-8,11,13-abietatrien-18 oate
There total 10 articles about methyl (15S)-16-(4-nitrobenzoyloxy)-8,11,13-abietatrien-18 oate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: borane-tetrahydrofuran complex / tetrahydrofuran / 1.) -10 -0 deg C, 10 min; 0-5 deg C, 3 h
2: 98.4 percent / pyridine / 1.5 h / 75 - 80 °C
3: aluminium chloride / CH2Cl2 / 1.) -10 deg C, 15 min; 2.) room temp., 64 h
4: 90.8 percent / m-chloroperbenzoic acid, p-toluenesulfonic acid / 1,2-dichloro-ethane / 3 h / Heating
5: 87 percent / 15percent hydrochloric acid / H2O; ethanol / 1 h / Heating
6: 91.1 percent / potassium carbonate / butan-2-one / 10 h / Heating
7: 40.7 percent / sodium carbonate / H2O; methanol / 2.5 h / Ambient temperature
8: 11.7 percent / hydrogen / 10percent Pd-C / ethanol / 85 h / 760 Torr
9: 96.5 percent / pyridine / 2.5 h / 70 - 80 °C
With
pyridine; hydrogenchloride; aluminium trichloride; borane-THF; hydrogen; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; butanone;
DOI:10.1246/bcsj.61.2405
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 98.4 percent / pyridine / 1.5 h / 75 - 80 °C
2: aluminium chloride / CH2Cl2 / 1.) -10 deg C, 15 min; 2.) room temp., 64 h
3: 90.8 percent / m-chloroperbenzoic acid, p-toluenesulfonic acid / 1,2-dichloro-ethane / 3 h / Heating
4: 87 percent / 15percent hydrochloric acid / H2O; ethanol / 1 h / Heating
5: 91.1 percent / potassium carbonate / butan-2-one / 10 h / Heating
6: 40.7 percent / sodium carbonate / H2O; methanol / 2.5 h / Ambient temperature
7: 11.7 percent / hydrogen / 10percent Pd-C / ethanol / 85 h / 760 Torr
8: 96.5 percent / pyridine / 2.5 h / 70 - 80 °C
With
pyridine; hydrogenchloride; aluminium trichloride; hydrogen; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid;
palladium on activated charcoal;
In
methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; butanone;
DOI:10.1246/bcsj.61.2405
