4-hydroxymethyl-5-(2-hydroxybut-3-en-2-yl)-1-methoxy-2-methylbenzene

Base Information

• Chemical Name: 4-hydroxymethyl-5-(2-hydroxybut-3-en-2-yl)-1-methoxy-2-methylbenzene
• CAS No.: 114092-42-1
• Molecular Formula: C₁₃H₁₈O₃
• Molecular Weight: 222.284
• Mol file: 114092-42-1.mol

Synonyms:4-hydroxymethyl-5-(2-hydroxybut-3-en-2-yl)-1-methoxy-2-methylbenzene

Chemical Property of 4-hydroxymethyl-5-(2-hydroxybut-3-en-2-yl)-1-methoxy-2-methylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-hydroxymethyl-5-(2-hydroxybut-3-en-2-yl)-1-methoxy-2-methylbenzene

There total 4 articles about 4-hydroxymethyl-5-(2-hydroxybut-3-en-2-yl)-1-methoxy-2-methylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-ethenyl-5-methoxy-3,6-dimethyl-1(3H)-isobenzofuranone (87503-68-2) → 4-hydroxymethyl-5-(2-hydroxybut-3-en-2-yl)-1-methoxy-2-methylbenzene (114092-42-1)

Guidance literature:

With lithium aluminium tetrahydride; diethyl ether; In tetrahydrofuran; for 0.5h; Ambient temperature;

Reference yield:

5-hydroxy-2,6-dimethyl-2-vinylphthalide (114092-37-4) → 4-hydroxymethyl-5-(2-hydroxybut-3-en-2-yl)-1-methoxy-2-methylbenzene (114092-42-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / diethyl ether / 18 h / Ambient temperature

2: 97 percent / LiAlH₄/ether / tetrahydrofuran / 0.5 h / Ambient temperature

With lithium aluminium tetrahydride; diethyl ether; In tetrahydrofuran; diethyl ether;

Reference yield:

4-methoxy-3-methylbenzoic acid (6880-04-2) → 4-hydroxymethyl-5-(2-hydroxybut-3-en-2-yl)-1-methoxy-2-methylbenzene (114092-42-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent

2: 2.) acid hydrolysis

3: LiAlH₄ / diethyl ether

With lithium aluminium tetrahydride; In diethyl ether;

upstream raw materials:

3-ethenyl-5-methoxy-3,6-dimethyl-1(3H)-isobenzofuranone

5-hydroxy-2,6-dimethyl-2-vinylphthalide

4-methoxy-3-methylbenzoic acid

1-<2-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-5-methoxy-4-methylphenyl>ethanone

Downstream raw materials:

4-acetoxymethyl-1-(2-hydroxybut-3-en-2-yl)-1-methoxy-2-methylbenzene

4-formyl-1-methoxy-2-methyl-5-(4-phenylsulphonylbut-2-en-2-yl)benzene

[2-((E)-3-Benzenesulfonyl-1-methyl-propenyl)-4-methoxy-5-methyl-phenyl]-methanol

1-methoxy-3-methoxycarbonyl-2-methyl-5-(4-phenylsulphonylbut-2-en-2-yl)benzene